TRIM proteins and cancer

被引：700
作者：
Hatakeyama, Shigetsugu [1 ,2 ]
机构：
[1] Hokkaido Univ, Dept Biochem, Inst Anim Expt, Grad Sch Med,Kita Ku, Sapporo, Hokkaido 0608638, Japan
[2] Hokkaido Univ, Grad Sch Med, Cent Inst Isotope Sci, Kita Ku, Sapporo, Hokkaido 0608638, Japan
来源：
NATURE REVIEWS CANCER | 2011年 / 11卷 / 11期
关键词：
ACUTE PROMYELOCYTIC LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; RET FINGER PROTEIN; ESTROGEN-RECEPTOR-ALPHA; TUMOR-SUPPRESSOR GENE; PML-RAR-ALPHA; LIGAND-DEPENDENT TRANSCRIPTION; TELANGIECTASIA GROUP-D; E3 UBIQUITIN LIGASE; RING FINGER;
D O I：
10.1038/nrc3139
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Emerging clinical evidence shows that the deregulation of ubiquitin-mediated degradation of oncogene products or tumour suppressors is likely to be involved in the aetiology of carcinomas and leukaemias. Recent studies have indicated that some members of the tripartite motif (TRIM) proteins (one of the subfamilies of the RING type E3 ubiquitin ligases) function as important regulators for carcinogenesis. This Review focuses on TRIM proteins that are involved in tumour development and progression.
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页码：792 / 804
页数：13
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