Persistent Smell Loss Following Undetectable SARS-CoV-2

被引:17
|
作者
Yan, Carol H. [1 ]
Prajapati, Divya P. [1 ,2 ]
Ritter, Michele L. [3 ]
DeConde, Adam S. [1 ]
机构
[1] Univ Calif San Diego Hlth, Dept Surg, Div Otolaryngol Head & Neck Surg, 9350 Campus Point Dr,Mail Code 0970, La Jolla, CA 92037 USA
[2] Univ Calif San Diego Hlth, Sch Med, La Jolla, CA USA
[3] Univ Calif San Diego Hlth, Dept Med, Div Infect Dis & Global Publ Hlth, La Jolla, CA USA
基金
美国国家卫生研究院;
关键词
smell loss; COVID-19; health care workers; SARS-CoV-2; health care policy;
D O I
10.1177/0194599820934769
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
The association of smell and taste loss with COVID-19 has been well demonstrated with high prevalence rates. In certain cases, chemosensory loss may be the only symptom of COVID-19 and may linger while other symptoms have resolved. The significance of persistent smell and taste loss and its relationship to ongoing viral shedding has yet to be investigated. In this cross-sectional study, of the 316 laboratory test-confirmed COVID-19 cases at our institution, 46 had subsequent test-based confirmation of viral clearance with 2 consecutive negative RT-PCR test results (reverse transcriptase polymerase chain reaction). Olfactory dysfunction was reported by 50% of the patients (23 of 46), with 78% (18 of 23) having subjective persistent smell loss despite negative RT-PCR test results. These preliminary data demonstrate the persistence of self-reported smell loss despite otherwise clinical resolution and undetectable nasal viral RNA.
引用
收藏
页码:923 / 925
页数:3
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