D-dimer in patients infected with COVID-19 and suspected pulmonary embolism

被引：56

作者：

Garcia-Olive, Ignasi ^{[1
,2
,3
]}

Sintes, Helena ^{[1
,4
]}

Radua, Joaquim ^{[5
,6
,7
,8
]}

Abad Capa, Jorge ^{[1
,2
,3
,4
]}

Rosell, Antoni ^{[1
,2
,3
,4
]}

机构：

[1] Hosp Badalona Germans Trias & Pujol, Serv Pneumol, Carretera Canyet Sn, Barcelona 08916, Spain

[2] Ciber Enfermedades Resp, CibeRes, Bunyola, Spain

[3] Germans Trias & Pujol Res Inst IGTP, Barcelona, Spain

[4] Univ Autonoma Barcelona, Dept Med, Barcelona, Spain

[5] Inst Invest Biomed August Pi i Sunyer IDIBAPS, Imaging Mood & Anxiety Related Disorders IMARD Gr, Barcelona, Spain

[6] CIBERSAM, Madrid, Spain

[7] Kings Coll London, Inst Psychiat Psychol & Neurosci, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England

[8] Karolinska Inst, Stockholm Cty Council, Dept Clin Neurosci, Stockholm Hlth Care Serv, Stockholm, Sweden

来源：

RESPIRATORY MEDICINE | 2020年 / 169卷

关键词：

COVID-19; D-dimer; Pulmonary embolism;

D O I：

10.1016/j.rmed.2020.106023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To analyze the risk factors for pulmonary embolism (PE) in patients infected with COVID-19. Methods: We conducted an observational, retrospective study. Patients with severe infection with COVID-19 and suspected PE were included. Results: Patients with higher levels of D-dimer and those requiring intubation were at a higher risk of developing PE. Higher D-dimer levels were associated with a greater probability of PE 3, 6, 9 and 12 days after determining D-dimer levels with an OR of 1.7, 2.0, 2.4 and 2.4, respectively. Conclusion: In conclusion, patients infected with COVID-19 requiring OTI with higher levels of D-dimer have an increased risk of developing PE.

引用

页数：3

共 9 条

[1] Fitting Linear Mixed-Effects Models Using lme4 [J].

Bates, Douglas ;

Maechler, Martin ;

Bolker, Benjamin M. ;

Walker, Steven C. .

JOURNAL OF STATISTICAL SOFTWARE, 2015, 67 (01) :1-48

[2] Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia [J].

Cui, Songping ;

Chen, Shuo ;

Li, Xiunan ;

Liu, Shi ;

Wang, Feng .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2020, 18 (06) :1421-1424

[3] Acute pulmonary embolism and COVID-19 pneumonia: a random association? [J].

Danzi, Gian Battista ;

Loffi, Marco ;

Galeazzi, Gianluca ;

Gherbesi, Elisa .

EUROPEAN HEART JOURNAL, 2020, 41 (19) :1858-1858

[4] Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic [J].

Driggin, Elissa ;

Madhavan, Mahesh V. ;

Bikdeli, Behnood ;

Chuich, Taylor ;

Laracy, Justin ;

Biondi-Zoccai, Giuseppe ;

Brown, Tyler S. ;

Nigoghossian, Caroline Der ;

Zidar, David A. ;

Haythe, Jennifer ;

Brodie, Daniel ;

Beckman, Joshua A. ;

Kirtane, Ajay J. ;

Stone, Gregg W. ;

Krumholz, Harlan M. ;

Parikh, Sahil A. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 75 (18) :2352-2371

[5] Hematologic parameters in patients with COVID-19 infection [J].

Fan, Bingwen Eugene ;

Chong, Vanessa Cui Lian ;

Chan, Stephrene Seok Wei ;

Lim, Gek Hsiang ;

Lim, Kian Guan Eric ;

Tan, Guat Bee ;

Mucheli, Sharavan Sadasiv ;

Kuperan, Ponnudurai ;

Ong, Kiat Hoe .

AMERICAN JOURNAL OF HEMATOLOGY, 2020, 95 (06) :E131-E134

[6] Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19 [J].

Gao, Yong ;

Li, Tuantuan ;

Han, Mingfeng ;

Li, Xiuyong ;

Wu, Dong ;

Xu, Yuanhong ;

Zhu, Yulin ;

Liu, Yan ;

Wang, Xiaowu ;

Wang, Linding .

JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (07) :791-796

[7]

Klok FA, 2020, THROMB RES, V191, P145, DOI [10.1016/j.thromres.2020.04.013, 10.1016/j.thromres.2020.04.041]

[8]

Tang N, 2020, J THROMB HAEMOST, V18, P844, DOI [10.1111/jth.14768, 10.1111/jth.14820]

[9] Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study [J].

Zhou, Fei ;

Yu, Ting ;

Du, Ronghui ;

Fan, Guohui ;

Liu, Ying ;

Liu, Zhibo ;

Xiang, Jie ;

Wang, Yeming ;

Song, Bin ;

Gu, Xiaoying ;

Guan, Lulu ;

Wei, Yuan ;

Li, Hui ;

Wu, Xudong ;

Xu, Jiuyang ;

Tu, Shengjin ;

Zhang, Yi ;

Chen, Hua ;

Cao, Bin .

LANCET, 2020, 395 (10229) :1054-1062

← 1 →