Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity

被引：118
作者：
Wilson, Micheal C. [1 ]
Moore, Bradley S. [1 ,2 ]
机构：
[1] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA
来源：
NATURAL PRODUCT REPORTS | 2012年 / 29卷 / 01期
关键词：
BIOSYNTHETIC GENE-CLUSTER; COENZYME-A REDUCTASE; FATTY-ACIDS; CHLOROETHYLMALONYL-COENZYME; MACROLIDE ANTIBIOTICS; ACETATE ASSIMILATION; GLYOXYLATE CYCLE; STREPTOMYCES SP; REVEROMYCIN-A; SYNTHASE;
D O I：
10.1039/c1np00082a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review covers the emerging biosynthetic role of crotonyl-CoA carboxylase/ reductase (CCR) homologs in extending the structural and functional diversity of polyketide natural products. CCRs catalyze the reductive carboxylation of alpha,beta-unsaturated acyl-CoA substrates to produce a variety of substituted malonyl-CoA derivatives employed as polyketide synthase extender units. Here we discuss the history of CCRs in both primary and secondary metabolism, the mechanism by which they function, examples of new polyketide diversity from pathway specific CCRs, and the role of CCRs in facilitating the bioengineering novel polyketides.
引用
收藏
页码：72 / 86
页数：15
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