Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity

被引：118

作者：

Wilson, Micheal C. ^{[1
]}

Moore, Bradley S. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

来源：

NATURAL PRODUCT REPORTS | 2012年 / 29卷 / 01期

关键词：

BIOSYNTHETIC GENE-CLUSTER; COENZYME-A REDUCTASE; FATTY-ACIDS; CHLOROETHYLMALONYL-COENZYME; MACROLIDE ANTIBIOTICS; ACETATE ASSIMILATION; GLYOXYLATE CYCLE; STREPTOMYCES SP; REVEROMYCIN-A; SYNTHASE;

D O I：

10.1039/c1np00082a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review covers the emerging biosynthetic role of crotonyl-CoA carboxylase/ reductase (CCR) homologs in extending the structural and functional diversity of polyketide natural products. CCRs catalyze the reductive carboxylation of alpha,beta-unsaturated acyl-CoA substrates to produce a variety of substituted malonyl-CoA derivatives employed as polyketide synthase extender units. Here we discuss the history of CCRs in both primary and secondary metabolism, the mechanism by which they function, examples of new polyketide diversity from pathway specific CCRs, and the role of CCRs in facilitating the bioengineering novel polyketides.

引用

页码：72 / 86

页数：15

共 92 条

[1] Multiple pathways for acetate assimilation in Streptomyces cinnamonensis [J].

Akopiants, K ;

Florova, G ;

Li, CX ;

Reynolds, KA .

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2006, 33 (02) :141-150

[2] Study of an alternate glyoxylate cycle for acetate assimilation by Rhodobacter sphaeroides [J].

Alber, Birgit E. ;

Spanheimer, Regina ;

Ebenau-Jehle, Christa ;

Fuchs, Georg .

MOLECULAR MICROBIOLOGY, 2006, 61 (02) :297-309

[3] Biotechnological potential of the ethylmalonyl-CoA pathway [J].

Alber, Birgit E. .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2011, 89 (01) :17-25

[4] Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica [J].

Beer, Laura L. ;

Moore, Bradley S. .

ORGANIC LETTERS, 2007, 9 (05) :845-848

[5]

BERKOZ B, 1959, P CHEM SOC LONDON, P316

[6] Streptomyces scabies 87-22 Contains a Coronafacic Acid-Like Biosynthetic Cluster That Contributes to Plant-Microbe Interactions [J].

Bignell, Dawn R. D. ;

Seipke, Ryan F. ;

Huguet-Tapia, Jose C. ;

Chambers, Alan H. ;

Parry, Ronald J. ;

Loria, Rosemary .

MOLECULAR PLANT-MICROBE INTERACTIONS, 2010, 23 (02) :161-175

[7] Biosynthesis of Thuggacins in Myxobacteria: Comparative Cluster Analysis Reveals Basis for Natural Product Structural Diversity [J].

Buntin, Kathrin ;

Irschik, Herbert ;

Weissman, Kira J. ;

Luxenburger, Eva ;

Bloecker, Helmut ;

Mueller, Rolf .

CHEMISTRY & BIOLOGY, 2010, 17 (04) :342-356

[8] Biosynthesis of polyketide synthase extender units [J].

Chan, Yolande A. ;

Podevels, Angela M. ;

Kevany, Brian M. ;

Thomas, Michael G. .

NATURAL PRODUCT REPORTS, 2009, 26 (01) :90-114

[9] Divergolides A-D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa-Macrolide Biosynthesis [J].

Ding, Ling ;

Maier, Armin ;

Fiebig, Heinz-Herbert ;

Goerls, Helmar ;

Lin, Wen-Han ;

Peschel, Gundela ;

Hertweck, Christian .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (07) :1630-1634

[10] Synthesis Of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase:: The ethylmalonyl-CoA pathway [J].

Erb, Tobias J. ;

Berg, Ivan A. ;

Brecht, Volker ;

Mueller, Michael ;

Fuchs, Georg ;

Alber, Birgit E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (25) :10631-10636

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