DESIGNER DRUGS: ANALYTICAL AND BIOLOGICAL ASPECTS

被引：12

作者：

Bulcao, Rachel ^{[1
]}

Garcia, Solange Cristina ^{[1
]}

Limberger, Renata Pereira ^{[1
]}

Baierle, Marilia ^{[1
]}

Arbo, Marcelo Dutra ^{[2
]}

da Matta Chasin, Alice Aparecida ^{[3
]}

Thiesen, Flavia Valladao ^{[4
]}

Tavares, Rejane ^{[5
]}

机构：

[1] Univ Fed Rio Grande do Sul, Dept Anal, Fac Farm, BR-90610000 Porto Alegre, RS, Brazil

[2] Fdn Estadual Prod & Pesquisa Saude, Ctr Informacao Toxicol Rio Grande Sul, BR-90650090 Porto Alegre, RS, Brazil

[3] Fac Oswaldo Cruz, BR-01151000 Sao Paulo, Brazil

[4] Pontificia Univ Catolica Rio Grande do Sul, Fac Farm, BR-90619900 Porto Alegre, RS, Brazil

[5] Univ Fed Ciencias Saude Porto Alegre, Dept Metodos Diagnost, BR-90050170 Porto Alegre, RS, Brazil

来源：

QUIMICA NOVA | 2012年 / 35卷 / 01期

关键词：

biological matrices; drug abuse; toxicology; CHROMATOGRAPHY-MASS SPECTROMETRY; SOLID-PHASE MICROEXTRACTION; PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN BLOOD-PLASMA; TOXICOLOGICAL DETECTION; RAT URINE; 4-BROMO-2,5-DIMETHOXYPHENETHYLAMINE 2C-B; ORAL FLUID; BIOANALYTICAL PROCEDURES; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA;

D O I：

10.1590/S0100-40422012000100027

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DESIGNER DRUGS: ANALYTICAL AND BIOLOGICAL ASPECTS. In the recent years, analytical toxicologists have been facing difficulties in detecting designer drugs due to the chemical modifications on the existing structures and the speed in which they are released into the market, requiring the development and improvement of specific and appropriate analytical methods. This work is a review of the literature which summarizes the characteristics of the drugs and the analytical validated methods using conventional and unconventional matrices currently used for correct identification and quantification of the following classes of emerging drugs of abuse: derivatives of opiates, amphetamines, tryptamines, piperazines and cannabinoids.

引用

页码：149 / 158

页数：10

共 128 条

[81] Simultaneous, quantitative determination of opiates, amphetamines, cocaine and benzoylecgonine in oral fluid by liquid chromatography quadrupole-time-of-flight mass spectrometry [J].

Mortier, KA ;

Maudens, KE ;

Lambert, WE ;

Clauwaert, KM ;

Van Bocxlaer, JF ;

Deforce, DL ;

Van Peteghem, CH ;

De Leenheer, AP .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2002, 779 (02) :321-330

[82] The synthetic cannabinoid Spice as a trigger for an acute exacerbation of cannabis induced recurrent psychotic episodes [J].

Mueller, Helge ;

Sperling, Wolfgang ;

Koehrmann, Martin ;

Huttner, Hagen B. ;

Kornhuber, Johannes ;

Maler, Juan-Manuel .

SCHIZOPHRENIA RESEARCH, 2010, 118 (1-3) :309-310

[83] Automated headspace solid-phase dynamic extraction for the determination of cannabinoids in hair samples [J].

Musshoff, F ;

Lachenmeier, DW ;

Kroener, L ;

Madea, B .

FORENSIC SCIENCE INTERNATIONAL, 2003, 133 (1-2) :32-38

[84] Determination of opioid analgesics in hair samples using liquid chromatography/tandem mass spectrometry and application to patients under palliative care [J].

Musshoff, Frank ;

Lachenmeier, Katrin ;

Trafkowski, Jens ;

Madea, Burkhard ;

Nauck, Friedemann ;

Stamer, Ulrike .

THERAPEUTIC DRUG MONITORING, 2007, 29 (05) :655-661

[85] The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain [J].

Nagai, Fumiko ;

Nonaka, Ryouichi ;

Kamimura, Kanako Satoh Hisashi .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 559 (2-3) :132-137

[86] Quantification of MDMA and MDA in abusers' hair samples by semi-micro column HPLC with fluorescence detection [J].

Nakamura, Shinichi ;

Tomita, Mamoru ;

Wada, Mitsuhiro ;

Chung, Heesun ;

Kuroda, Naotaka ;

Nakashima, Kenichiro .

BIOMEDICAL CHROMATOGRAPHY, 2006, 20 (6-7) :622-627

[87] Colorimetric detection and chromatographic analyses of designer drugs in biological materials: a comprehensive review [J].

Namera, Akira ;

Nakamoto, Akihiro ;

Saito, Takeshi ;

Nagao, Masataka .

FORENSIC TOXICOLOGY, 2011, 29 (01) :1-24

[88]

Navarro M, 2001, CLIN CHEM, V47, P1788

[89] DIFFERENCES BETWEEN THE MECHANISM OF ACTION OF MDMA, MBDB, AND THE CLASSIC HALLUCINOGENS - IDENTIFICATION OF A NEW THERAPEUTIC CLASS - ENTACTOGENS [J].

NICHOLS, DE .

JOURNAL OF PSYCHOACTIVE DRUGS, 1986, 18 (04) :305-313

[90]

OGA S., 2008, Fundamentos de Toxicologia, V3a

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