DESIGNER DRUGS: ANALYTICAL AND BIOLOGICAL ASPECTS

被引：12
作者：
Bulcao, Rachel [1 ]
Garcia, Solange Cristina [1 ]
Limberger, Renata Pereira [1 ]
Baierle, Marilia [1 ]
Arbo, Marcelo Dutra [2 ]
da Matta Chasin, Alice Aparecida [3 ]
Thiesen, Flavia Valladao [4 ]
Tavares, Rejane [5 ]
机构：
[1] Univ Fed Rio Grande do Sul, Dept Anal, Fac Farm, BR-90610000 Porto Alegre, RS, Brazil
[2] Fdn Estadual Prod & Pesquisa Saude, Ctr Informacao Toxicol Rio Grande Sul, BR-90650090 Porto Alegre, RS, Brazil
[3] Fac Oswaldo Cruz, BR-01151000 Sao Paulo, Brazil
[4] Pontificia Univ Catolica Rio Grande do Sul, Fac Farm, BR-90619900 Porto Alegre, RS, Brazil
[5] Univ Fed Ciencias Saude Porto Alegre, Dept Metodos Diagnost, BR-90050170 Porto Alegre, RS, Brazil
来源：
QUIMICA NOVA | 2012年 / 35卷 / 01期
关键词：
biological matrices; drug abuse; toxicology; CHROMATOGRAPHY-MASS SPECTROMETRY; SOLID-PHASE MICROEXTRACTION; PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN BLOOD-PLASMA; TOXICOLOGICAL DETECTION; RAT URINE; 4-BROMO-2,5-DIMETHOXYPHENETHYLAMINE 2C-B; ORAL FLUID; BIOANALYTICAL PROCEDURES; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA;
D O I：
10.1590/S0100-40422012000100027
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
DESIGNER DRUGS: ANALYTICAL AND BIOLOGICAL ASPECTS. In the recent years, analytical toxicologists have been facing difficulties in detecting designer drugs due to the chemical modifications on the existing structures and the speed in which they are released into the market, requiring the development and improvement of specific and appropriate analytical methods. This work is a review of the literature which summarizes the characteristics of the drugs and the analytical validated methods using conventional and unconventional matrices currently used for correct identification and quantification of the following classes of emerging drugs of abuse: derivatives of opiates, amphetamines, tryptamines, piperazines and cannabinoids.
引用
收藏
页码：149 / 158
页数：10
相关论文
共 128 条
[1]   'Spice' and other herbal blends: harmless incense or cannabinoid designer drugs? [J].
Auwaerter, Volker ;
Dresen, Sebastian ;
Weinmann, Wolfgang ;
Mueller, Michael ;
Puetz, Michael ;
Ferreiros, Nerea .
JOURNAL OF MASS SPECTROMETRY, 2009, 44 (05) :832-837
[2]  
Barone JA, 1997, J PHARM PRACTICE, V10, P292, DOI DOI 10.1177/089719009701000409
[3]  
Battu C, 1998, J CHROMATOGR SCI, V36, P1
[4]   Effects of "Legal X" piperazine analogs on dopamine and serotonin release in rat brain [J].
Baumann, MH ;
Clark, RD ;
Budzynski, AG ;
Partilla, JS ;
Blough, BE ;
Rothman, RB .
CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 2004, 1025 :189-197
[5]   N-substituted piperazines abused by humans mimic the molecular mechanism of 3,4-methylenedioxymethamphetamine (MDMA, or 'Ecstasy') [J].
Baumann, MH ;
Clark, RD ;
Budzynski, AG ;
Partilla, JS ;
Blough, BE ;
Rothman, RB .
NEUROPSYCHOPHARMACOLOGY, 2005, 30 (03) :550-560
[6]  
Blanke R.V., 1996, CASARETT DOULLS TOXI, P905
[7]   Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection [J].
Boatto, G ;
Nieddu, M ;
Carta, A ;
Pau, A ;
Palomba, M ;
Asproni, B ;
Cerri, R .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2005, 814 (01) :93-98
[8]  
BUCHANAN JF, 1988, MED TOXICOL ADV DRUG, V3, P1
[9]   Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human [J].
Carmo, H ;
Hengstler, JG ;
de Boer, D ;
Ringel, M ;
Remiao, F ;
Carvalho, F ;
Fernandes, E ;
dos Reys, LA ;
Oesch, F ;
Bastos, MD .
TOXICOLOGY, 2005, 206 (01) :75-89
[10]   Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in mice, after acute administration [J].
Carmo, H ;
de Boer, D ;
Remiao, F ;
Carvalho, F ;
dos Reys, LA ;
Bastos, MD .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2004, 811 (02) :143-152
12345678910