Implications of Vascular Aging

被引：77

作者：

Barodka, Viachaslau M. ^{[1
]}

Joshi, Brijen L. ^{[1
]}

Berkowitz, Dan E. ^{[1
]}

Hogue, Charles W., Jr. ^{[1
]}

Nyhan, Daniel ^{[1
]}

机构：

[1] Johns Hopkins Univ Hosp, Johns Hopkins Med Inst, Dept Anesthesiol Crit Care Med, Baltimore, MD 21287 USA

来源：

ANESTHESIA AND ANALGESIA | 2011年 / 112卷 / 05期

基金：

美国国家卫生研究院;

关键词：

PULSE-WAVE VELOCITY; ARTERY FUNCTION EVALUATION; BLOOD-PRESSURE REDUCTION; CENTRAL AORTIC PRESSURES; WHITE-MATTER LESIONS; INDEPENDENT PREDICTOR; AUGMENTATION INDEX; HEART-RATE; ALL-CAUSE; CARDIOVASCULAR MORTALITY;

D O I：

10.1213/ANE.0b013e3182147e3c

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Chronological age is a well-established risk factor for the development of cardiovascular diseases. The changes that accumulate in the vasculature with age, however, are highly variable. It is now increasingly recognized that indices of vascular health are more reliable than age per se in predicting adverse cardiovascular outcomes. The variation in the accrual of these age-related vascular changes is a function of multiple genetic and environmental factors. In this review, we highlight some of the pathophysiological mechanisms that characterize the vascular aging phenotype. Furthermore, we provide an overview of the key outcome studies that address the value of these vascular health indices in general and discuss potential effects on perioperative cardiovascular outcomes. (Anesth Analg 2011;112:1048-60)

引用

页码：1048 / 1060

页数：13

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