The application of next-generation sequencing technologies to drug discovery and development

被引：25

作者：

Woollard, Peter M. ^{[1
]}

Mehta, Nalini A. L. ^{[2
]}

Vamathevan, Jessica J. ^{[1
]}

Van Horn, Stephanie ^{[3
]}

Bonde, Bhushan K. ^{[1
]}

Dow, David J. ^{[2
]}

机构：

[1] GlaxoSmithKline Res & Dev Ltd, Computat Biol Drug Discovery, Stevenage SG1 2NY, Herts, England

[2] GlaxoSmithKline Res & Dev Ltd, Mol & Cellular Technol, Platform Technol & Sci, Stevenage SG1 2NY, Herts, England

[3] GlaxoSmithKline Res & Dev Ltd, Mol & Cellular Technol, Platform Technol & Sci, Collegeville, PA 19426 USA

来源：

DRUG DISCOVERY TODAY | 2011年 / 16卷 / 11-12期

关键词：

ACUTE MYELOID-LEUKEMIA; HUMAN GENOME; DNA; CANCER; VARIANTS; DIAGNOSTICS; GENES; MAPS;

D O I：

10.1016/j.drudis.2011.03.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Next-generation sequencing (NGS) technologies represent a paradigm shift in sequencing capability. The technology has already been extensively applied to biological research, resulting in significant and remarkable insights into the molecular biology of cells. In this review, we focus on current and potential applications of the technology as applied to the drug discovery and development process. Early applications have focused on the oncology and infectious disease therapeutic areas, with emerging use in biopharmaceutical development and vaccine production in evidence. Although this technology has great potential, significant challenges remain, particularly around the storage, transfer and analysis of the substantial data sets generated.

引用

页码：512 / 519

页数：8

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