Convergent synthesis of internally branched PAMAM dendrimers

被引:41
作者
Pittelkow, M [1 ]
Christensen, JB [1 ]
机构
[1] Univ Copenhagen, Dept Chem, DK-2100 Copenhagen, Denmark
关键词
D O I
10.1021/ol050040d
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A series of aliphatic internally branched poly(amido amine) dendrons and dendrimers has been synthesized. The internal branching unit was 1,2-propanediamine and a series of PAMAM-type dendrons of the types AB2, AB4, and ABB were built. These were anchored on a core molecule containing four carboxylic acid moieties and the 1,2-propanediamine unit resulted in PAMAM dendrimers with 4, 8, 16, and 32 end groups.
引用
收藏
页码:1295 / 1298
页数:4
相关论文
共 38 条
[1]   Synthesis and biological evaluation of α-D-mannopyranoside-containing dendrimers [J].
Ashton, PR ;
Hounsell, EF ;
Jayaraman, N ;
Nilsen, TM ;
Spencer, N ;
Stoddart, JF ;
Young, M .
JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (10) :3429-3437
[2]   About dendrimers: Structure, physical properties, and applications [J].
Bosman, AW ;
Janssen, HM ;
Meijer, EW .
CHEMICAL REVIEWS, 1999, 99 (07) :1665-1688
[3]  
Brouwer AJ, 2001, EUR J ORG CHEM, V2001, P1903
[4]  
BUHLEIER E, 1978, SYNTHESIS-STUTTGART, P155
[5]   POLY(PROPYLENE IMINE) DENDRIMERS - LARGE-SCALE SYNTHESIS BY HETEREOGENEOUSLY CATALYZED HYDROGENATIONS [J].
DEBRABANDERVANDENBERG, EMM ;
MEIJER, EW .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1993, 32 (09) :1308-1311
[6]  
Denkewalter R. G., 1981, [No title captured], Patent No. [4289872, US 4289872A]
[7]  
Frechet J.M.J., 2001, WILEY SERIES POLYM S
[8]   POLYAMINOPHOSPHINES CONTAINING DENDRIMERS - SYNTHESES AND CHARACTERIZATIONS [J].
GALLIOT, C ;
PREVOTE, D ;
CAMINADE, AM ;
MAJORAL, JP .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (20) :5470-5476
[9]   Convergent dendrons and dendrimers:: from synthesis to applications [J].
Grayson, SM ;
Fréchet, JMJ .
CHEMICAL REVIEWS, 2001, 101 (12) :3819-3867
[10]  
Greene T. W., 1999, PROTECTIVE GROUPS OR