High frequency deep brain stimulation: What are the therapeutic mechanisms?

被引：57

作者：

Liu, Ying ^{[1
]}

Postupna, Nadia ^{[1
]}

Falkenberg, Jon ^{[1
]}

Anderson, Marjorie E. ^{[1
]}

机构：

[1] Univ Washington, Natl Primate Res Ctr, Dept Rehabil Med & Physiol & Biophys, Seattle, WA 98195 USA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2008年 / 32卷 / 03期

关键词：

deep brain stimulation; subthalamic nucleus; internal globus pallidus; Parkinson's disease;

D O I：

10.1016/j.neubiorev.2006.10.007

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

High frequency deep brain stimulation (HFS) used to treat the symptoms of Parkinson's disease (PD) was first assumed to act by directly by mechanisms such as depolarization block or activation of presynaptic inhibitory fibers, and the same mechanisms evoked by HFS in the subthalamic nucleus (STN) could reduce the excitatory action of STN on GPi neurons. Although somatic recordings from neurons near the stimulation site may appear to support this potential mechanism, the action downstream from the site of stimulation often is not consistent with this interpretation. A more parsimonious explanation for the similar effects of HFS in STN or GPi and a lesion of either of these structures is that both HFS and pallidotomy interrupt an abnormal pattern of firing in cortico-basal gangliathalamocortical loops that is responsible for the symptoms of PD. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：343 / 351

页数：9

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