Immunomodulatory Effect of (-)-Matairesinol in Vivo and ex Vivo

被引：19

作者：

Yamawaki, Manami ^{[1
]}

Nishi, Kosuke ^{[1
]}

Nishimoto, Sogo ^{[2
]}

Yamauchi, Satoshi ^{[1
,3
]}

Akiyama, Koichi ^{[4
]}

Kishida, Taro ^{[1
,3
]}

Maruyama, Masafumi ^{[1
]}

Nishiwaki, Hisashi ^{[1
]}

Sugahara, Takuya ^{[1
,3
]}

机构：

[1] Ehime Univ, Fac Agr, Matsuyama, Ehime 7908566, Japan

[2] Ehime Univ, Ctr Marine Environm Studies, Matsuyama, Ehime 7908577, Japan

[3] Ehime Univ, S Ehime Fisheries Res Ctr, Ainan, Ehime 7984292, Japan

[4] Ehime Univ, Tarumi Stn, Integrated Ctr Sci, Matsuyama, Ehime 7908566, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2011年 / 75卷 / 05期

关键词：

gut immunity; lignan; matairesinol; IgE; ANTIOXIDANT ACTIVITY; LIGNANS; IDENTIFICATION; SECOISOLARICIRESINOL;

D O I：

10.1271/bbb.100781

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Matairesinol is one of the lignan compounds found in a variety of plant foodstuffs. We investigated the immunomodulatory effects of (-)-matairesinol in vivo and ex vivo by using mice. Although we found no significant differences in the IgG, IgA and IgM levels in the serum, the IgE level was strongly suppressed by the uptake of (-)-matairesinol in both intact and ovalbumin-immunized mice. The immunoglobulin produced by lymphocytes from the spleen was not activated by the intake of (-)-matairesinol. However, lymphocytes in such gut-associated lymphatic tissues as Peyer's patches and mesenteric lymph nodes were activated by the administration of (-)-matairesinol.

引用

页码：859 / 863

页数：5

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