Nutrition support can bring survival benefit to high nutrition risk gastric cancer patients who received chemotherapy

被引：62

作者：

Qiu, Miaozhen ^{[1
,6
]}

Zhou, Yi-xin ^{[1
]}

Jin, Yin ^{[1
]}

Wang, Zi-xian ^{[2
]}

Wei, Xiao-li ^{[1
]}

Han, Hong-yu ^{[3
]}

Ye, Wen-feng ^{[3
]}

Zhou, Zhi-wei ^{[4
]}

Zhang, Dong-sheng ^{[1
]}

Wang, Feng-hua ^{[1
]}

Li, Yu-hong ^{[1
]}

Yang, Da-jun ^{[5
]}

Xu, Rui-hua ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, Dept Med Oncol,State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Fac Med Sci, Guangzhou 510060, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, Dept Clin Nutr,State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, Dept Gastr & Pancreat Surg,State Key Lab Oncol So, Guangzhou 510060, Guangdong, Peoples R China

[5] Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, Dept Expt Res,State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China

[6] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

来源：

SUPPORTIVE CARE IN CANCER | 2015年 / 23卷 / 07期

基金：

国家高技术研究发展计划(863计划);

关键词：

Nutritional Risk Screening 2002; Gastric cancer; Nutrition support; China; WEIGHT-LOSS; COLORECTAL-CANCER; COMPLICATIONS; MALNUTRITION; METASTASES; CARCINOMA; SURGERY;

D O I：

10.1007/s00520-014-2523-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of our study is firstly to evaluate the prevalence and prognostic value of nutrition risk in gastric cancer patients and secondly to explore whether the nutrition support can prolong the survival of advanced gastric cancer patients. It contained two study periods. In the first period, we prospectively evaluated the nutritional risk of gastric adenocarcinoma patients from 2009 to 2011 using the method of European Nutritional Risk Screening (NRS) 2002. The Kaplan-Meier method and log-rank test were used to evaluate the prognostic value of high nutrition risk. The second period was between 2012 and 2013. We prospectively gave the nutrition support to stage IV gastric cancer patients whose NRS is a parts per thousand yen3. There were 830 patients in the first period, 50.7 % patients with a NRS a parts per thousand yenaEuro parts per thousand 3. Patients with NRS a parts per thousand yenaEuro parts per thousand 3 presented a significantly higher percentage of stage IV diseases, elevated values of C-reactive protein, and hypoproteinemia. The median survival was significantly higher in NRS < 3 patients (31.9 vs. 25.7 months, P < 0.001). Multivariate analysis confirmed that NRS status was an independent prognostic factor. There were 347 patients in the second period. Young, male, and good response to chemotherapy were more likely to have the NRS shift to < 3 after nutrition support. The median survival was 14.3 and 9.6 months for patients with and without NRS shift, respectively, P = 0.001. NRS a parts per thousand yenaEuro parts per thousand 3 was an independent adverse prognostic factor in gastric cancer patients. For stage IV patients whose NRS a parts per thousand yenaEuro parts per thousand 3, the nutrition support might be helpful to improve the prognosis.

引用

页码：1933 / 1939

页数：7

共 21 条

[1] PROGNOSTIC FACTORS INFLUENCING SURVIVAL OF PATIENTS WITH ADVANCED COLORECTAL-CANCER - HEPATIC-ARTERY INFUSION VERSUS SYSTEMIC INTRAVENOUS CHEMOTHERAPY FOR LIVER METASTASES [J].