Repairing nucleosomes during transcription

被引：4

作者：

Carrozza, MJ ^{[1
]}

Kusch, T ^{[1
]}

Workman, JL ^{[1
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO 64110 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2003年 / 10卷 / 11期

关键词：

D O I：

10.1038/nsb1103-879

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies suggest that the Spt16 protein of FACT shuttles H2A-H2B dimers off and on nucleosomes during transcription elongation. By restoring nucleosomes after passage of RNA polymerase II, Spt16 and Spt6 prevent transcription from cryptic promoters in coding regions that would otherwise be expressed in the absence of histones.

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收藏

页码：879 / 880

页数：2

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