Molecular systems biology in drug development

被引：13
作者：
Silver, P. A. [1 ]
Way, J. C.
机构：
[1] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA
[2] EMD Serono Lexigen Res Ctr, Billerica, MA USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2007年 / 82卷 / 05期
关键词：
D O I：
10.1038/sj.clpt.6100293
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Molecular systems biology seeks to explain the behavior of complex cellular systems through a multicomponent analysis. We illustrate this approach and its relevance to drug development by reviewing two examples of the interplay between cellular processes and drugs: the internalization and recycling of oncogenic receptors, their ligands and therapeutic antibodies; and strategies for discovering drugs that affect intracellular protein kinase pathways.
引用
收藏
页码：586 / 590
页数：5
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