Emerging hydrogel designs for controlled protein delivery

被引：44

作者：

Bae, Ki Hyun ^{[1
]}

Kurisawa, Motoichi ^{[1
]}

机构：

[1] Inst Bioengn & Nanotechnol, 31 Biopolis Way, Singapore 138669, Singapore

来源：

BIOMATERIALS SCIENCE | 2016年 / 4卷 / 08期

关键词：

INTERPENETRATING POLYMER NETWORKS; POLY(ETHYLENE GLYCOL) HYDROGELS; ENGINEERED PEG HYDROGELS; CONTROLLED DRUG-DELIVERY; AQUEOUS 2-PHASE SYSTEMS; IN-VITRO ASSESSMENT; HYALURONIC-ACID; COMPLEX COACERVATION; BIOMEDICAL APPLICATIONS; CONTROLLED-RELEASE;

D O I：

10.1039/c6bm00330c

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Hydrogels have evolved into indispensable biomaterials in the fields of drug delivery and regenerative medicine. This minireview aims to highlight the recent advances in the hydrogel design for controlled release of bioactive proteins. The latest developments of enzyme-responsive and externally regulated drug delivery systems are summarized. The design strategies and applications of phase-separated hydrogel systems are also described. We expect that these emerging approaches will enable expanded use of hydrogels in biomedicine and healthcare.

引用

页码：1184 / 1192

页数：9

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