Emerging hydrogel designs for controlled protein delivery

被引：43
作者：
Bae, Ki Hyun [1 ]
Kurisawa, Motoichi [1 ]
机构：
[1] Inst Bioengn & Nanotechnol, 31 Biopolis Way, Singapore 138669, Singapore
来源：
BIOMATERIALS SCIENCE | 2016年 / 4卷 / 08期
关键词：
INTERPENETRATING POLYMER NETWORKS; POLY(ETHYLENE GLYCOL) HYDROGELS; ENGINEERED PEG HYDROGELS; CONTROLLED DRUG-DELIVERY; AQUEOUS 2-PHASE SYSTEMS; IN-VITRO ASSESSMENT; HYALURONIC-ACID; COMPLEX COACERVATION; BIOMEDICAL APPLICATIONS; CONTROLLED-RELEASE;
D O I：
10.1039/c6bm00330c
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Hydrogels have evolved into indispensable biomaterials in the fields of drug delivery and regenerative medicine. This minireview aims to highlight the recent advances in the hydrogel design for controlled release of bioactive proteins. The latest developments of enzyme-responsive and externally regulated drug delivery systems are summarized. The design strategies and applications of phase-separated hydrogel systems are also described. We expect that these emerging approaches will enable expanded use of hydrogels in biomedicine and healthcare.
引用
收藏
页码：1184 / 1192
页数：9
相关论文
共 91 条
  • [1] Human Neutrophil Elastase Responsive Delivery from Poly(ethylene glycol) Hydrogels
    Aimetti, Alex A.
    Tibbitt, Mark W.
    Anseth, Kristi S.
    [J]. BIOMACROMOLECULES, 2009, 10 (06) : 1484 - 1489
  • [2] Albertsson P A, 1970, Adv Protein Chem, V24, P309, DOI 10.1016/S0065-3233(08)60244-2
  • [3] PARTITION OF PROTEINS IN AQUEOUS POLYMER 2-PHASE SYSTEMS AND THE EFFECT OF MOLECULAR-WEIGHT OF THE POLYMER
    ALBERTSSON, PA
    CAJARVILLE, A
    BROOKS, DE
    TJERNELD, F
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 926 (01) : 87 - 93
  • [4] Aqueous two-phase systems for protein separation: A perspective
    Asenjo, Juan A.
    Andrews, Barbara A.
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (49) : 8826 - 8835
  • [5] Microstructured dextran hydrogels for burst-free sustained release of PEGylated protein drugs
    Bae, Ki Hyun
    Lee, Fan
    Xu, Keming
    Keng, Choong Tat
    Tan, Sue Yee
    Tan, Yee Joo
    Chen, Qingfeng
    Kurisawa, Motoichi
    [J]. BIOMATERIALS, 2015, 63 : 146 - 157
  • [6] Injectable biodegradable hydrogels: progress and challenges
    Bae, Ki Hyun
    Wang, Li-Shan
    Kurisawa, Motoichi
    [J]. JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (40) : 5371 - 5388
  • [7] Ultrasound-Modulated Shape Memory and Payload Release Effects in a Biodegradable Cylindrical Rod Made of Chitosan-Functionalized PLGA Microspheres
    Bao, Min
    Zhou, Qihui
    Dong, Wen
    Lou, Xiangxin
    Zhang, Yanzhong
    [J]. BIOMACROMOLECULES, 2013, 14 (06) : 1971 - 1979
  • [8] Stimuli-responsive polymers and their applications in drug delivery
    Bawa, Priya
    Pillay, Viness
    Choonara, Yahya E.
    du Toit, Lisa C.
    [J]. BIOMEDICAL MATERIALS, 2009, 4 (02)
  • [9] PULSATILE INSULIN DELIVERY - PHYSIOLOGY AND CLINICAL IMPLICATIONS
    BRATUSCHMARRAIN, PR
    KOMJATI, M
    WALDHAUSL, W
    [J]. DIABETIC MEDICINE, 1987, 4 (03) : 197 - 200
  • [10] EFFICACY OF PULSATILE VERSUS CONTINUOUS INSULIN ADMINISTRATION ON HEPATIC GLUCOSE-PRODUCTION AND GLUCOSE-UTILIZATION IN TYPE-I DIABETIC HUMANS
    BRATUSCHMARRAIN, PR
    KOMJATI, M
    WALDHAUSL, WK
    [J]. DIABETES, 1986, 35 (08) : 922 - 926
12345678910