The Interaction Between Contactin and Amyloid Precursor Protein and Its Role in Alzheimer's Disease

被引：27

作者：

Bamford, Rosemary A. ^{[1
]}

Widagdo, Jocelyn ^{[2
]}

Takamura, Natsuki ^{[1
,3
]}

Eve, Madeline ^{[1
]}

Anggono, Victor ^{[2
]}

Oguro-Ando, Asami ^{[1
]}

机构：

[1] Univ Exeter, Med Sch, Exeter EX2 5DW, Devon, England

[2] Univ Queensland, Queensland Brain Inst, Clem Jones Ctr Ageing Dementia Res, Brisbane, Qld, Australia

[3] Univ Tokyo, Grad Sch Arts & Sci, Meguro Ku, 3-8-1 Komaba, Tokyo, Japan

来源：

NEUROSCIENCE | 2020年 / 424卷

基金：

芬兰科学院;

关键词：

Alzheimer's disease; Contactin; amyloid precursor protein; synaptic plasticity; RECOGNITION MOLECULE NB-3; CELL-ADHESION MOLECULE; GENOME-WIDE ASSOCIATION; LONG-TERM POTENTIATION; SERUM URIC-ACID; SYNAPTIC PLASTICITY; MYELINATED AXONS; CEREBROSPINAL-FLUID; NERVOUS-SYSTEM; APP FAMILY;

D O I：

10.1016/j.neuroscience.2019.10.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is a debilitating disease and the most common cause of dementia. As the world population ages even modest advances in therapies and preventative strategies would be of benefit. The specific physiological function of the amyloid precursor protein (APP) remains unclear despite strong genetic and biochemical evidence of APP involvement in AD. The intricate molecular processes of the nervous system rely on interactions between cell surface receptors coupled to intracellular downstream signaling networks. APP is an integral membrane protein which interacts with members of the Contactin family of proteins. Here we review recent progresses in the field and discuss the physiological importance of APP-Contactin interaction, as well as their roles and contributions in the pathophysiology of AD. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：184 / 202

页数：19

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