Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance

被引：312

作者：

Wei, Tuo ^{[1
,2
,3
,4
,5
,6
,7
]}

Chen, Chao ^{[2
,8
]}

Liu, Juan ^{[1
,2
,7
]}

Liu, Cheng ^{[2
,9
]}

Posocco, Paola ^{[10
]}

Liu, Xiaoxuan ^{[2
,3
,4
,5
,6
]}

Cheng, Qiang ^{[11
]}

Huo, Shuaidong ^{[1
,7
]}

Liang, Zicai ^{[11
]}

Fermeglia, Maurizio ^{[10
]}

Pricl, Sabrina ^{[10
]}

Liang, Xing-Jie ^{[1
]}

Rocchi, Palma ^{[3
,4
,5
,6
]}

Peng, Ling ^{[2
]}

机构：

[1] Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[2] Aix Marseille Univ, CNRS, Ctr Interdisciplinaire Nanosci Marseille, UMR 7325, F-13288 Marseille, France

[3] Ctr Rech Cancerol Marseille, INSERM U1068, F-13009 Marseille, France

[4] Inst J Paoli I Calmettes, F-13009 Marseille, France

[5] Univ Aix Marseille 2, F-13284 Marseille, France

[6] CNRS UMR7258, F-13009 Marseille, France

[7] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[8] Aix Marseille Univ, CNRS, Inst Chim Radicalaire, UMR 7273, F-13390 Marseille, France

[9] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

[10] Univ Trieste, Dept Engn & Architecture, Mol Simulat Engn Lab, I-34127 Trieste, Italy

[11] Peking Univ, Lab Nucle Acid Technol, Inst Mol Med, Beijing 100871, Peoples R China

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2015年 / 112卷 / 10期

关键词：

amphiphilic dendrimers; supramolecular nanomicelles; drug delivery; cancer treatment; nanodrugs; MULTIDRUG-RESISTANCE; MACROMOLECULAR THERAPEUTICS; MOLECULAR-MECHANISMS; STARBURST DENDRIMERS; IN-VIVO; DELIVERY; SIZE; NANOTECHNOLOGY; DOXORUBICIN; NANOPARTICLES;

D O I：

10.1073/pnas.1418494112

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Drug resistance and toxicity constitute challenging hurdles for cancer therapy. The application of nanotechnology for anticancer drug delivery is expected to address these issues and bring new hope for cancer treatment. In this context, we established an original nanomicellar drug delivery system based on an amphiphilic dendrimer (AmDM), which could generate supramolecular micelles to effectively encapsulate the anticancer drug doxorubicin (DOX) with high drug-loading capacity (> 40%), thanks to the unique dendritic structure creating large void space for drug accommodation. The resulting AmDM/DOX nanomicelles were able to enhance drug potency and combat doxorubicin resistance in breast cancer models by significantly enhancing cellular uptake while considerably decreasing efflux of the drug. In addition, the AmDM/DOX nanoparticles abolished significantly the toxicity related to the free drug. Collectively, our studies demonstrate that the drug delivery system based on nanomicelles formed with the self-assembling amphiphilic dendrimer constitutes a promising and effective drug carrier in cancer therapy.

引用

页码：2978 / 2983

页数：6

共 38 条

[1] Double-degradable responsive self-assembled multivalent arrays - temporary nanoscale recognition between dendrons and DNA [J].