The renin-angiotensin system and the brain

被引：8

作者：

Molina-Van den Bosch, M. ^{[1
]}

Jacobs-Cacha, C. ^{[1
]}

Vergara, A. ^{[1
]}

Seron, D. ^{[1
]}

Soler, M. J. ^{[1
]}

机构：

[1] Vail Hebron Hosp Univ, Grp Nefrol, Vail Hebron Inst Recerca VHIR, Serv Nefrol,Vall Hebron Barcelona Hosp, Barcelona, Spain

来源：

HIPERTENSION Y RIESGO VASCULAR | 2021年 / 38卷 / 03期

关键词：

Renin-angiotensin system; ACE2; Cerebral; Sympathetic system; SYMPATHETIC-NERVE ACTIVITY; PARAVENTRICULAR NUCLEUS; COGNITIVE IMPAIRMENT; SELECTIVE DELETION; BLOOD-PRESSURE; MOUSE MODEL; EXPRESSION; TISSUE; RAAS; IV;

D O I：

10.1016/j.hipert.2020.12.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The renin-angiotensin-aldosterone (RAAS) system and its effects on blood pressure and the regulation of water and electrolyte balance have been studied focusing on the cardiovascular and renal system. The activation of RAAS in other organs has local and systemic repercussions by modeling the macro- and microvasculture of peripheral organs. The brain RAAS influence on systemic blood pressure through the sympathetic nervous system. The angiotensin converting enzyme/angiotensin II/angiotensin 1 receptor axis (ACE/AngII/AT1), classical pathway, and angiotensin converting enzyme type 2/angiotensin (1-7)/Mas receptor (ACE2/Ang (1-7)/MasR), non-classical pathway, are involved in the modulation of the sympathetic response. The imbalance of these two axes with subsequently Ang II accumulation promote neurogenic hypertension and other vascular pathologies. The aminopeptidase/angiotensin IV/angiotensin 4 receptor (AMN/Ang IV/AT4) axis, which is exclusive of the brain, acts on cerebral microvasculature and participates in cognition, memory, and learning. The aim of this review is to decipher the major central RAAS mechanisms involved in blood pressure regulation. In addition, paracrine functions of brain RAAS and its role in neuroprotection and cognition are also described in this review. (c) 2020 SEH-LELHA. Published by Elsevier Espana, S.L.U. All rights reserved.

引用

页码：125 / 132

页数：8

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