Toxicity of nitric oxide and peroxynitrite to bacterial pathogens of fish

被引：42
作者：
Campos-Pérez, JJ
Ellis, AE
Secombes, CJ
机构：
[1] Univ Aberdeen, Dept Zool, Aberdeen AB24 2TZ, Scotland
[2] FRS Marine Lab, Aberdeen AB11 9DB, Scotland
来源：
DISEASES OF AQUATIC ORGANISMS | 2000年 / 43卷 / 02期
关键词：
SNAP; SIN-1; nitric oxide; peroxynitrite; Renibacterium salmoninarum; Aeromonas salmonicida; Yersinia ruckeri;
D O I：
10.3354/dao043109
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
The inhibitory effect of the nitric oxide (NO) donor S-nitroso-acetyl-penicillamine (SNAP) and the NO and O-2(-) donor 3-morpholino-sydnonimine hydrochloride (SIN-1) was tested in a cell-free assay. Strains of the bacterial fish pathogens Aeromonas salmonicida, Renibacterium salmoninarum and Yersinia ruckeri were exposed to different concentrations of the NO donors for 24 h. The results showed that NO possesses inhibitory properties, while peroxynitrite had no effect. However, when SIN-1 was used in combination with superoxide dismutase (SOD) alone or with catalase, an inhibitory effect comparable to that caused by SNAP was seen. The implications of these results are discussed.
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收藏
页码：109 / 115
页数：7
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