Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery

被引：425

作者：

Shi, Liwang ^{[1
]}

Zhang, Jinqiu ^{[2
]}

Zhao, Man ^{[1
]}

Tang, Shukun ^{[1
]}

Cheng, Xu ^{[1
]}

Zhang, Wenyuan ^{[1
]}

Li, Wenhua ^{[1
]}

Liu, Xiaoying ^{[1
]}

Peng, Haisheng ^{[1
]}

Wang, Qun ^{[3
]}

机构：

[1] Harbin Med Univ, Dept Pharmaceut, Daqing Campus,1 Xinyang Rd, Daqing 163319, Peoples R China

[2] Daqing Normal Univ, Dept Foreign Language, Xibin Rd, Daqing 163712, Peoples R China

[3] Iowa State Univ, Dept Chem & Biol Engn, Ames, IA 50011 USA

来源：

NANOSCALE | 2021年 / 13卷 / 24期

基金：

中国国家自然科学基金;

关键词：

ACCELERATED BLOOD CLEARANCE; POLY(ETHYLENE GLYCOL); PEGYLATED LIPOSOMES; GOLD NANOPARTICLES; GRAFTING DENSITY; MOLECULAR-WEIGHT; CELLULAR UPTAKE; CHAIN-LENGTH; PEPTIDE NANOSPHERES; PROTEIN ADSORPTION;

D O I：

10.1039/d1nr02065j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The rapid development of drug nanocarriers has benefited from the surface hydrophilic polymers of particles, which has improved the pharmacokinetics of the drugs. Polyethylene glycol (PEG) is a kind of polymeric material with unique hydrophilicity and electrical neutrality. PEG coating is a crucial factor to improve the biophysical and chemical properties of nanoparticles and is widely studied. Protein adherence and macrophage removal are effectively relieved due to the existence of PEG on the particles. This review discusses the PEGylation methods of nanoparticles and related techniques that have been used to detect the PEG coverage density and thickness on the surface of the nanoparticles in recent years. The molecular weight (MW) and coverage density of the PEG coating on the surface of nanoparticles are then described to explain the effects on the biophysical and chemical properties of nanoparticles.

引用

页码：10748 / 10764

页数：17

共 189 条

[1] Negative Charging of Au Nanoparticles during Methanol Synthesis from CO2/H2 on a Au/ZnO Catalyst: Insights from Operando IR and Near-Ambient-Pressure XPS and XAS Measurements [J].

Abdel-Mageed, Ali M. ;

Klyushin, Alexander ;

Rezvani, Azita ;

Knop-Gericke, Axel ;

Schloegl, Robert ;

Behm, Juergen .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 58 (30) :10325-10329

[2] Effects of the PEG molecular weight of a PEG-lipid and cholesterol on PEG chain flexibility on liposome surfaces [J].

Abe, Kozue ;

Higashi, Kenjirou ;

Watabe, Keiko ;

Kobayashi, Ai ;

Limwikrant, Waree ;

Yamamoto, Keiji ;

Moribe, Kunikazu .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2015, 474 :63-70

[3] Ligand Density and Linker Length are Critical Factors for Multivalent Nanoparticle-Receptor Interactions [J].

Abstiens, Kathrin ;

Gregoritza, Manuel ;

Goepferich, Achim M. .

ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (01) :1311-1320

[4] Low versus high molecular weight poly(ethylene glycol)-induced states of stem bromelain at low pH: Stabilization of molten globule and unfolden states [J].

Ahmad, B ;

Ansari, MA ;

Sen, P ;

Khan, RH .

BIOPOLYMERS, 2006, 81 (05) :350-359

[5] ADSORPTION OF CHAIN MOLECULES WITH A POLAR HEAD A-SCALING DESCRIPTION [J].

ALEXANDER, S .

JOURNAL DE PHYSIQUE, 1977, 38 (08) :983-987

[6] Single-Walled Carbon Nanotube Surface Control of Complement Recognition and Activation [J].

Andersen, Alina J. ;

Robinson, Joshua T. ;

Dai, Hongjie ;

Hunter, A. Christy ;

Andresen, Thomas L. ;

Moghimi, S. Moein .

ACS NANO, 2013, 7 (02) :1108-1119

[7] Ocular disposition of ciprofloxacin from topical, PEGylated nanostructured lipid carriers: Effect of molecular weight and density of poly (ethylene) glycol [J].

Balguri, Sai Prachetan ;

Adelli, Goutham R. ;

Janga, Karthik Yadav ;

Bhagav, Prakash ;

Majumdar, Soumyajit .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 529 (1-2) :32-43

[8] Interactions of active carbon with low- and high-molecular weight polyethylene glycol and polyethylene oxide [J].

Bar-Chaput, S ;

Carrot, C .

JOURNAL OF APPLIED POLYMER SCIENCE, 2006, 100 (05) :3490-3497

[9] Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure-property relationships to better defined therapeutics [J].

Barz, Matthias ;

Luxenhofer, Robert ;

Zentel, Rudolf ;

Vicent, Maria J. .

POLYMER CHEMISTRY, 2011, 2 (09) :1900-1918

[10] Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology [J].

Bertrand, Nicolas ;

Wu, Jun ;

Xu, Xiaoyang ;

Kamaly, Nazila ;

Farokhzad, Omid C. .

ADVANCED DRUG DELIVERY REVIEWS, 2014, 66 :2-25

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