A new method for the synthesis of plurisubstituted pyrroles

被引：40

作者：

Bashiardes, G ^{[1
]}

Safir, I ^{[1
]}

Barbot, F ^{[1
]}

Laduranty, J ^{[1
]}

机构：

[1] Univ Poitiers, Dept Chem, SFA, UMR 6514, F-86022 Poitiers, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 46期

关键词：

D O I：

10.1016/j.tetlet.2003.09.099

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile method for the synthesis of pyrroles is described using an intramolecular [3+2] cycloaddition reaction. This method allows the expedient preparation of 'plurisubstituted' compounds in which functionality is incorporated by choice, using appropriate readily available starting materials. Polycyclic pyrrole derivatives as well as 2-aryl monocyclic analogues are described. Several families of compounds are synthesized by sequential transformations. The method is designed to allow the creation of libraries with increased diversity of functionality by combinatorial or parallel synthesis. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：8417 / 8420

页数：4

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