Penicillin-binding proteins and β-lactam resistance

被引：479
作者：
Zapun, Andre [1 ]
Contreras-Martel, Carlos [2 ]
Vernet, Thierry [1 ]
机构：
[1] Univ Grenoble 1, CEA, UMR CNRS 5075, Inst Biol Struct Jean Pierre Ebel,Lab Ingn Macrom, F-38027 Grenoble, France
[2] Univ Grenoble 1, CEA, UMR CNRS 5075, Inst Biol Struct Jean Pierre Ebel,Lab Proteines M, F-38027 Grenoble, France
来源：
FEMS MICROBIOLOGY REVIEWS | 2008年 / 32卷 / 02期
关键词：
Staphylococcus aureus; Streptococcus pneumoniae; Neisseria; Enterococcus;
D O I：
10.1111/j.1574-6976.2007.00095.x
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A number of ways and means have evolved to provide resistance to eubacteria challenged by beta-lactams. This review is focused on pathogens that resist by expressing low-affinity targets for these antibiotics, the penicillin-binding proteins (PBPs). Even within this narrow focus, a great variety of strategies have been uncovered such as the acquisition of an additional low-affinity PBP, the overexpression of an endogenous low-affinity PBP, the alteration of endogenous PBPs by point mutations or homologous recombination or a combination of the above.
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收藏
页码：361 / 385
页数：25
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