The course of substance use disorders in patients with borderline personality disorder and Axis II comparison subjects: a 10-year follow-up study

被引:51
作者
Zanarini, Mary C. [1 ]
Frankenbur, Frances R. [1 ]
Weingeroff, Jolie L. [1 ]
Reich, D. Bradford [1 ]
Fitzmaurice, Garrett M. [1 ]
Weiss, Roger D. [1 ]
机构
[1] McLean Hosp, Belmont, MA 02478 USA
关键词
Alcohol abuse; dependence; borderline personality disorder; drug abuse; longitudinal course; new onsets; recurrences; remissions; NATIONAL EPIDEMIOLOGIC SURVEY; TEST-RETEST RELIABILITY; DIAGNOSTIC INTERVIEW; DSM-III; ALCOHOL-ABUSE; UNITED-STATES; COMORBIDITY; DEPENDENCE; REMISSION; PSYCHOPATHOLOGY;
D O I
10.1111/j.1360-0443.2010.03176.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Aim The purpose of this study is to detail the course of substance use disorders (SUDs) over 10 years of prospective follow-up among patients with borderline personality disorder (BPD) and Axis II comparison subjects. Design This study uses data from the McLean Study of Adult Development (MSAD), a multi-faceted study of the longitudinal course of BPD using reliable repeated measures administered every 2 years over a decade of prospective follow-up. Setting All subjects were initially in-patients at McLean Hospital in Belmont Massachusetts. Participants A total of 290 patients with BPD and 72 Axis II comparison subjects were assessed at baseline and five waves of follow-up. Measurements The Structured Clinical Interview for DSM-III-R Axis I Disorders (SCID-I), the Revised Diagnostic Interview for Borderlines (DIB-R) and the Diagnostic Interview for DSM-III-R Personality Disorders (DIPD-R) were administered six times. Generalized estimating equations were used to assess longitudinal prevalence of SUDs. Kaplan-Meier analyses were used to assess time-to-remission, recurrence and new onsets of SUDs. Results The prevalence of SUDs among borderline patients and Axis II comparison subjects declined significantly over time, while remaining significantly more common among those with BPD. More than 90% of borderline patients meeting criteria for a SUD at baseline experienced a remission by 10-year follow-up. Recurrences and new onsets of SUDs were less common (35-40% and 21-23%). Conclusions Remissions of alcohol and drug abuse/dependence among borderline patients are both common and relatively stable. Results also suggest that new onsets of these disorders are less common than might be expected.
引用
收藏
页码:342 / 348
页数:7
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