Heart rate reduction in cardiovascular disease and therapy

被引：83

作者：

Reil, Jan-Christian ^{[1
]}

Custodis, Florian ^{[1
]}

Swedberg, Karl ^{[2
]}

Komajda, Michel ^{[3
]}

Borer, Jeffrey S. ^{[4
]}

Ford, Ian ^{[5
]}

Tavazzi, Luigi ^{[6
]}

Laufs, Ulrich ^{[1
]}

Boehm, Michael ^{[1
]}

机构：

[1] Univ Klinikum Saarlandes, Klin Innere Med Kardiol Angiol & Internist Intens, D-66421 Homburg, Germany

[2] Univ Gothenburg, Dept Emergency & Cardiovasc Med, Sahlgrenska Acad, S-41685 Gothenburg, Sweden

[3] Univ Paris 06, Dept Cardiol, La Pitie Salpetriere Hosp, Paris, France

[4] SUNY Hlth Sci Ctr, Div Cardiovasc Med, Howard Gilman Inst Heart Valve Dis, Brooklyn, NY 11203 USA

[5] Univ Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland

[6] Maria Cecilia Hosp, GVM Care & Res, Cotignola, Italy

来源：

CLINICAL RESEARCH IN CARDIOLOGY | 2011年 / 100卷 / 01期

关键词：

Heart rate; Selective heart rate reduction; Coronary heart disease; Heart failure; SYSTOLIC DYSFUNCTION BEAUTIFUL; CORONARY-ARTERY-DISEASE; BETA-BLOCKER; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION; EJECTION FRACTION; FAILURE; ATHEROSCLEROSIS; IVABRADINE; PLAQUE;

D O I：

10.1007/s00392-010-0207-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart rate influences myocardial oxygen demand, coronary blood flow, and myocardial function. Clinical and experimental studies support an association between elevated resting heart rate and a broad range of maladaptive effects on the function and structure of the cardiovascular system. Heart rate has been shown to be an important predictor of mortality in cardiovascular disorders such as coronary artery disease, myocardial infarction, and chronic heart failure. This review summarizes the specific influence of heart rate on vascular morphology and function as well as on myocardial lesions leading from early impact on vascular homeostasis to myocardial hemodynamics in chronic heart failure. Heart rate can be easily determined during physical examination of the patient and therefore allows a simple hint on prognosis and efficiency of therapy.

引用

页码：11 / 19

页数：9

共 55 条

[11] ALBUMINURIA REFLECTS WIDESPREAD VASCULAR DAMAGE - THE STENO HYPOTHESIS [J].