Application of click chemistry towards an efficient synthesis of 1,2,3-1H-triazolyl glycohybrids as enzyme inhibitors

被引：62

作者：

Anand, Namarata ^{[1
]}

Jaiswal, Natasha ^{[2
]}

Pandey, Sarvesh Kumar ^{[1
]}

Srivastava, A. K. ^{[2
]}

Tripathi, Rama P. ^{[1
]}

机构：

[1] Cent Drug Res Inst CSIR, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst CSIR, Div Biochem, Lucknow 226001, Uttar Pradesh, India

来源：

CARBOHYDRATE RESEARCH | 2011年 / 346卷 / 01期

关键词：

Click chemistry; CuAAC; Glycosyl triazoles; alpha-Glucosidase; Glucose-6-phosphatase; Glycogen phosphorylase; ESCHERICHIA-COLI; BIOLOGICAL EVALUATION; MAMMALIAN GALECTINS; TRIAZOLES; ADHESION; BINDING; AZIDE; 1,2,3-TRIAZOLES; DERIVATIVES; ALKYNES;

D O I：

10.1016/j.carres.2010.10.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient synthesis of novel 1,2,3-1H-triazolyl glycohybrids with two or more than two sugar units or a chromenone moiety via copper-catalysed azide-alkyne cycloaddition (CuAAC), a 1,3-dipolar cycloaddition of glycosyl azides to 2,3-unsaturated alkynyl glycosides or propargyloxy coumarins is described. The synthesised glycohybrids were screened for their a-glucosidase, glycogen phosphorylase and glucose-6-phosphatase inhibitory activities. A few of the glycohybrids showed promising inhibitory activities against these enzymes. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：16 / 25

页数：10

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