Positive effects of allosteric modulators on the binding properties and the function of muscarinic acetylcholine receptors

被引：10

作者：

Tucek, S

Jakubik, J

Dolezal, V

El-Fakahany, EE

机构：

[1] Inst Physiol AV CR, Prague 14220, Czech Republic

[2] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 3-4期

关键词：

muscarinic receptors; presynaptic receptors; allosteric regulation; alcuronium; acetylcholine;

D O I：

10.1016/S0928-4257(98)80026-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Data are reviewed indicating that allosteric modulators can enhance the affinities of muscarinic receptors for their antagonists and agonists, that the enhancement of the affinity for agonists is relevant functionally, and that the allosterically induced conformational change also affects the interaction between the receptors and the G proteins. ((C)Elsevier, Paris).

引用

页码：241 / 243

页数：3

共 28 条

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