Benzotriazole mediated syntheses of α-fluoro-β-amino esters

被引：23

作者：

Katritzky, AR ^{[1
]}

Nichols, DA ^{[1
]}

Qi, M ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(98)01520-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mono- and difluoro-beta-amino esters were synthesized via Reformatsky reaction of fluorinated ethyl bromoacetates with N-(alpha-aminoalkyl)benzotriazoles. Secondary and tertiary amines are easily formed, but primary amines can only be made in the difluorinated case. This approach has led to the first synthesis of di- and tetrafluorinated bis(beta-amino esters). (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7063 / 7066

页数：4

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