Human Alu element retrotransposition induced by genotoxic stress

被引：103

作者：

Hagan, CR

Sheffield, RF

Rudin, CM ^{[1
]}

机构：

[1] Univ Chicago, Div Biol Sci, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[3] Univ Chicago, Comm Canc Biol, Chicago, IL 60637 USA

来源：

NATURE GENETICS | 2003年 / 35卷 / 03期

关键词：

D O I：

10.1038/ng1259

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Alu elements are found exclusively in primate species and comprise over 10% of the human genome. To better define the mechanisms responsible for Alu replication, we introduced a human Alu element into mouse cells. We report that Alu retrotransposition can be induced in mouse cells by exposure to the topoisomerase II inhibitor etoposide and is mediated in trans by endogenous mouse long interspersed elements (LINEs).

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页码：219 / 220

页数：2

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