Gut Virome and Inflammatory Bowel Disease

被引：42

作者：

Lopetuso, Loris R. ^{[1
,2
]}

Ianiro, Gianluca ^{[1
]}

Scaldaferri, Franco ^{[1
]}

Cammarota, Giovanni ^{[1
]}

Gasbarrini, Antonio ^{[1
]}

机构：

[1] Univ Hosp A Gemelli, Div Gastroenterol, Dept Internal Med, Largo A Gemelli 1, I-00168 Rome, Italy

[2] Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA

来源：

INFLAMMATORY BOWEL DISEASES | 2016年 / 22卷 / 07期

关键词：

gut virome; gut microbiota; IBD; gut barrier; gut inflammation; GENOME-WIDE ASSOCIATION; SIMPLEX-VIRUS TYPE-1; LONG TERMINAL REPEAT; CROHNS-DISEASE; METAGENOMIC ANALYSIS; SUSCEPTIBILITY LOCI; VIRAL COMMUNITY; MICROBIOTA; INFECTION; DYNAMICS;

D O I：

10.1097/MIB.0000000000000807

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Gut virome has been shown to yield some beneficial effects on humans, being deeply involved in physiology, inflammation, immunity, and disease. Together with transkingdom interactions, it can interplay with genetic variation in the host to establish specific phenotypes. These interactions can lead to phenotypes not observed with either the virus or the host variation alone. Unfavorable alteration of gut virome composition has been implicated in chronic, and perhaps also systemic, immune disorders, such as in the pathogenesis of inflammatory bowel disease. This review focuses on what is currently known regarding the role of commensal gut virome in chronic gut inflammation, and speculate on the important translational implications in regard to gut virome modulation in inflammatory bowel disease with the end goal of promoting gut health.

引用

页码：1708 / 1712

页数：5

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