A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants

被引：2

作者：

Schmitz, Aaron J. ^{[1
]}

Turner, Jackson S. ^{[1
]}

Liu, Zhuoming ^{[2
]}

Zhou, Julian Q. ^{[1
]}

Aziati, Ishmael D. ^{[3
]}

Chen, Rita E. ^{[1
,3
]}

Joshi, Astha ^{[3
]}

Bricker, Traci L. ^{[3
]}

Darling, Tamarand L. ^{[3
]}

Adelsberg, Daniel C. ^{[4
]}

Altomare, Clara G. ^{[4
]}

Alsoussi, Wafaa B. ^{[1
,2
]}

Case, James Brett ^{[3
]}

VanBlargan, Laura A. ^{[3
]}

Lei, Tingting ^{[1
]}

Thapa, Mahima ^{[1
]}

Amanat, Fatima ^{[4
,5
]}

Jeevan, Trushar ^{[6
]}

Fabrizio, Thomas ^{[6
]}

O'Halloran, Jane A. ^{[3
]}

Shi, Pei-Yong ^{[7
]}

Presti, Rachel M. ^{[3
,8
]}

Webby, Richard J. ^{[6
]}

Krammer, Florian ^{[4
]}

Whelan, Sean P. J. ^{[2
]}

Bajic, Goran ^{[4
]}

Diamond, Michael S. ^{[1
,2
,3
,8
,9
]}

Boon, Adrianus C. M. ^{[1
,2
,3
]}

Ellebedy, Ali H. ^{[1
,2
,8
,9
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA

[2] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[4] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, New York, NY 10029 USA

[6] St Jude Childrens Res Hosp, Dept Infect Dis, 332 N Lauderdale St, Memphis, TN 38105 USA

[7] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA

[8] Washington Univ, Ctr Vaccines & Immun Microbial Pathogens, Sch Med, St Louis, MO 63130 USA

[9] Washington Univ, Andrew M & Jane M Bursky Ctr Human Immunol & Immu, Sch Med, St Louis, MO 63130 USA

来源：

IMMUNITY | 2021年 / 54卷 / 09期

关键词：

NEUTRALIZING ANTIBODIES; SEQUENCE ALIGNMENT; REPERTOIRE; CELL;

D O I：

10.1016/j.immuni.2021.08.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The emergence of SARS-CoV-2 antigenic variants with increased transmissibility is a public health threat. Some variants show substantial resistance to neutralization by SARS-CoV-2 infection- or vaccination-induced antibodies. Here, we analyzed receptor binding domain-binding monoclonal antibodies derived from SARS-CoV-2 mRNA vaccine-elicited germinal center B cells for neutralizing activity against the WA1/2020 D614G SARS-CoV-2 strain and variants of concern. Of five monoclonal antibodies that potently neutralized the WA1/2020 D614G strain, all retained neutralizing capacity against the B.1.617.2 variant, four also neutralized the B.1.1.7 variant, and only one, 2C08, also neutralized the B.1.351 and B.1.1.28 variants. 2C08 reduced lung viral load and morbidity in hamsters challenged with the WA1/2020 D614G, B.1.351, or B.1.617.2 strains. Clonal analysis identified 2C08-like public clonotypes among B cells responding to SARS-CoV-2 infection or vaccination in 41 out of 181 individuals. Thus, 2C08-like antibodies can be induced by SARS-CoV-2 vaccines and mitigate resistance by circulating variants of concern.

引用

页码：2159 / +

页数：14

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