Is placebo analgesia mediated by endogenous opioids? A systematic review

被引：76
作者：
ter Riet, G
de Craen, AJM
de Boer, A
Kessels, AGH
机构：
[1] Univ Limburg, Dept Epidemiol, NL-6200 MD Maastricht, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol & Biostat, NL-1100 DE Amsterdam, Netherlands
[3] UIPS, Dept Pharmacoepidemiol & Pharmacotherapy, NL-3508 TB Utrecht, Netherlands
来源：
PAIN | 1998年 / 76卷 / 03期
关键词：
endorphins; naloxone; placebo analgesia; proglumide; review;
D O I：
10.1016/S0304-3959(98)00057-8
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
This systematic review assesses six experimental studies into the mechanism of placebo analgesia in human subjects suffering from clinical pain or experimentally induced ischaemic arm pain. Due to their sophisticated designs, these studies probably provide the best evidence that placebo analgesia exists. They also indicate that placebo analgesia is mediated by endogenous opiates. However, there seems to be room for additional studies. (C) 1998 International Association for the Study of Pain. Published by Elsevier Science B.V.
引用
收藏
页码：273 / 275
页数：3
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