Immunomodulatory Effects of Tryptophan Metabolism in the Glioma Tumor Microenvironment

被引：12
作者：
Xu, Yang [1 ]
Zhang, Huikai [1 ]
Sun, Qian [1 ]
Geng, Rongxin [1 ]
Yuan, Fanen [1 ]
Liu, Baohui [1 ]
Chen, Qianxue [1 ]
机构：
[1] Wuhan Univ, Dept Neurosurg, Renmin Hosp, Wuhan, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
基金：
中国国家自然科学基金;
关键词：
glioma; tryptophan; metabolism; immunomodulation; tumor microenvironment; ARYL-HYDROCARBON RECEPTOR; AMINO-ACID-METABOLISM; INDOLEAMINE 2,3-DIOXYGENASE 1; REGULATORY T-CELLS; CANCER SUPPRESSION; GENE-EXPRESSION; DENDRITIC CELLS; KYNURENINE; GLIOBLASTOMA; MACROPHAGES;
D O I：
10.3389/fimmu.2021.730289
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Gliomas are the most common primary malignant tumor in adults' central nervous system. While current research on glioma treatment is advancing rapidly, there is still no breakthrough in long-term treatment. Abnormalities in the immune regulatory mechanism in the tumor microenvironment are essential to tumor cell survival. The alteration of amino acid metabolism is considered a sign of tumor cells, significantly impacting tumor cells and immune regulation mechanisms in the tumor microenvironment. Despite the fact that the metabolism of tryptophan in tumors is currently discussed in the literature, we herein focused on reviewing the immune regulation of tryptophan metabolism in the tumor microenvironment of gliomas and analyzed possible immune targets. The objective is to identify potential targets for the treatment of glioma and improve the efficiency of immunotherapy.
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页数：9
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