Comparison of Myocardial Remodeling between Cryoinfarction and Reperfused Infarction in Mice

被引：21

作者：

Duerr, Georg D. ^{[1
]}

Elhafi, Naziha ^{[2
]}

Bostani, Toktam ^{[1
]}

Ellinger, Joerg ^{[3
]}

Swieny, Louay ^{[1
]}

Kolobara, Elvis ^{[1
]}

Welz, Armin ^{[1
]}

Dewald, Oliver ^{[1
]}

机构：

[1] Univ Clin Ctr Bonn, Dept Cardiac Surg, D-53105 Bonn, Germany

[2] Univ Clin Ctr Bonn, Inst Physiol 1, D-53105 Bonn, Germany

[3] Univ Clin Ctr Bonn, Dept Urol, D-53105 Bonn, Germany

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2011年

关键词：

ISCHEMIC CARDIOMYOPATHY; CELLULAR CARDIOMYOPLASTY; INFLAMMATORY RESPONSE; CELLS; CARDIOMYOCYTES; MODEL; MOUSE;

D O I：

10.1155/2011/961298

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Myocardial infarction is associated with inflammatory reaction leading to tissue remodeling. We compared tissue remodeling between cryoinfarction (cMI) and reperfused myocardial infarction (MI) in order to better understand the local environment where we apply cell therapies. Models of closed-chest one-hour ischemia/reperfusion MI and cMI were used in C57/Bl6-mice. The reperfused MI showed rapid development of granulation tissue and compacted scar formation after 7 days. In contrast, cMI hearts showed persistent cardiomyocyte debris and cellular infiltration after 7 days and partially compacted scar formation accompanied by persistent macrophages and myofibroblasts after 14 days. The mRNA of proinflammatory mediators was transiently induced in MI and persistently upregulated in cMI. Tenascin C and osteopontin-1 showed delayed induction in cMI. In conclusion, the cryoinfarction was associated with prolonged inflammation and active myocardial remodeling when compared to the reperfused MI. These substantial differences in remodeling may influence cellular engraftment and should be considered in cell therapy studies.

引用

页数：10

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