The known and missing links between Toxoplasma gondii and schizophrenia

被引：53
|
作者：
Elsheikha, Hany M. [1 ]
Busselberg, Dietrich [2 ]
Zhu, Xing-Quan [3 ]
机构：
[1] Univ Nottingham, Sch Vet Med & Sci, Fac Med & Hlth Sci, Loughborough LE12 5RD, Leics, England
[2] Qatar Fdn Educ City, Weill Cornell Med Coll Qatar, POB 24144, Doha, Qatar
[3] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Vet Parasitol Gansu Prov, State Key Lab Vet Etiol Biol, Lanzhou 730046, Gansu, Peoples R China
来源：
METABOLIC BRAIN DISEASE | 2016年 / 31卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Toxoplasma gondii; Schizophrenia; Mental illness; Psychosis; Host-pathogen interaction; OBSESSIVE-COMPULSIVE DISORDER; LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM; C-REACTIVE PROTEIN; BIPOLAR DISORDER; INFECTED MICE; OXIDATIVE STRESS; INTERFERON-GAMMA; CELL-CULTURES; DOPAMINE;
D O I：
10.1007/s11011-016-9822-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Toxoplasma gondii, an intracellular protozoan parasite, has a striking predilection for infecting the Central Nervous System and has been linked to an increased incidence of a number of psychiatric diseases. Several in vitro and in vivo studies have shown that T. gondii infection can affect the structure, bioenergetics and function of brain cells, and alters several host cell processes, including dopaminergic, tryptophan-kynurenine, GABAergic, AKT1, Jak/STAT, and vasopressinergic pathways. These mechanisms underlying the neuropathology of latent toxoplasmosis seem to operate also in schizophrenia, supporting the link between the two disorders. Better understanding of the intricate parasite-neuroglial communications holds the key to unlocking the mystery of T. gondii-mediated schizophrenia and offers substantial prospects for the development of disease-modifying therapies.
引用
收藏
页码：749 / 759
页数：11
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