Curcumin, the golden spice in treating cardiovascular diseases

被引：242

作者：

Li, Hong ^{[1
,2
]}

Sureda, Antoni ^{[3
,4
]}

Devkota, Hari Prasad ^{[5
]}

Pittala, Valeria ^{[6
]}

Barreca, Davide ^{[7
]}

Silva, Ana Sanches ^{[8
,9
]}

Tewari, Devesh ^{[10
]}

Xu, Suowen ^{[11
]}

Nabavi, Seyed Mohammad ^{[12
]}

机构：

[1] Guangzhou Univ Chinese Med, Dept Biochem & Mol Biol, Guangzhou 510006, Guangdong, Peoples R China

[2] Guangzhou Univ Chinese Med, Res Ctr Basic Integrat Med, Guangzhou 510006, Guangdong, Peoples R China

[3] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma de Mallorca, Spain

[4] Inst Salud Carlos III, CIBEROBN, Physiopathol Obes & Nutr CB12 03 30038, Madrid, Spain

[5] Kumamoto Univ, Sch Pharm, Chuo Ku, 5-1 Oe Honmachi, Kumamoto 8620973, Japan

[6] Univ Catania, Dept Drug Sci, Viale Andrea Doria 6, I-95125 Catania, Italy

[7] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale F Stagno dAlcontres 31, I-98166 Messina, Italy

[8] Natl Inst Agr & Vet Res INIAV, Rua Lagidos, P-4485655 Oporto, Portugal

[9] Univ Porto, ICETA, Ctr Study Anim Sci CECA, Oporto, Portugal

[10] Kumaun Univ, Fac Technol, Dept Pharmaceut Sci, Bhimtal Campus, Naini Tal, Uttarakhand, India

[11] Univ Rochester, Aab Cardiovasc Res Inst, Rochester, NY 14623 USA

[12] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran 1435916471, Iran

来源：

BIOTECHNOLOGY ADVANCES | 2020年 / 38卷

关键词：

Curcumin; Nutraceuticals; Cardiovascular diseases; Molecular targets; Clinical trials; NF-KAPPA-B; ISCHEMIA-REPERFUSION INJURY; HIGH-FAT DIET; HISTONE ACETYLTRANSFERASE ACTIVITY; PREVENTS DIABETIC CARDIOMYOPATHY; MICROVASCULAR ENDOTHELIAL-CELLS; SPONTANEOUSLY HYPERTENSIVE-RATS; INDUCED MYOCARDIAL-INFARCTION; THORACIC AORTIC-ANEURYSM; TERMINAL KINASE PATHWAY;

D O I：

10.1016/j.biotechadv.2019.01.010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cardiovascular diseases (CVDs) cause the largest mortality worldwide, and much attention has been focused to unravel the mechanisms and optimize the treatment regimens. Curcumin is an important bioactive component of turmeric that has been widely applied as traditional medicine to prevent and treat various diseases in some countries. Recent studies have demonstrated its potent activities in modulating multiple signaling pathways associated with cellular growth, proliferation, survival, inflammation and oxidative stress. The cardiovascular protective properties of curcumin in CVDs have been fully illustrated in numerous studies. In this review, we first briefly introduce the medicinal history of curcumin. Secondly, we systematically analyze the preclinical studies of curcumin in CVDs such as cardiac hypertrophy, heart failure, drug-induced cardiotoxicity, myocardial infarction, atherosclerosis, abdominal aortic aneurysm, stroke and diabetic cardiovascular complications. The potential molecular targets of curcumin are also summarized. Thirdly, the clinical trials of curcumin in CVDs are overviewed and discussed. Finally, we discuss the therapeutic utility of derivatives of curcumin, and highlight existing problems of curcumin as an effective drug lead in treating CVDs.

引用

页数：15

共 218 条

[1] Curcumin reduces cold storage-induced damage in human cardiac myoblasts [J].

Abuarqoub, Hadil ;

Green, Colin J. ;

Foresti, Roberta ;

Motterlini, Roberto .

EXPERIMENTAL AND MOLECULAR MEDICINE, 2007, 39 (02) :139-148

[2] Guidelines for the early management of adults with ischemic stroke -: A guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups (Reprinted from Stroke, vol 38, pg 1655-1711, 2007) [J].

Adams, Harold P., Jr. ;

del Zoppo, Gregory ;

Alberts, Mark J. ;

Bhatt, Deepak L. ;

Brass, Lawrence ;

Furlan, Anthony ;

Grubb, Robert L. ;

Higashida, Randall T. ;

Jauch, Edward C. ;

Kidwell, Chelsea ;

Lyden, Patrick D. ;

Morgenstern, Lewis B. ;

Qureshi, Adnan I. ;

Rosenwasser, Robert H. ;

Scott, Phillip A. ;

Wijdicks, Eelco F. M. .

CIRCULATION, 2007, 115 (20) :E478-E534

[3] Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases [J].

Aggarwal, Bharat B. ;

Harikumar, Kuzhuvelil B. .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2009, 41 (01) :40-59

[4] Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits [J].

Ahn, Chan Mug ;

Park, Byong-Gon ;

Woo, Ho Bum ;

Ham, Jungyeob ;

Shin, Woon-Seob ;

Lee, Seokjoon .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (05) :1481-1483

[5] Curcumin: a potential therapeutic polyphenol, prevents noradrenaline-induced hypertrophy in rat cardiac myocytes [J].

Ahuja, Suchit ;

Kohli, Shrey ;

Krishnan, Shruti ;

Dogra, Deepika ;

Sharma, Dinesh ;

Rani, Vibha .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, 63 (12) :1604-1612

[6] Curcumin as a wound healing agent [J].

Akbik, Dania ;

Ghadiri, Maliheh ;

Chrzanowski, Wojciech ;

Rohanizadeh, Ramin .

LIFE SCIENCES, 2014, 116 (01) :1-7

[7] Evaluation of the antioxidant properties of curcumin derivatives by genetic function algorithm [J].

Alisi, Ikechukwu Ogadimma ;

Uzairu, Adamu ;

Abechi, Stephen Eyije ;

Idris, Sulaiman Ola .

JOURNAL OF ADVANCED RESEARCH, 2018, 12 :47-54

[8] Is Chronic Curcumin Supplementation Neuroprotective Against Ischemia for Antioxidant Activity, Neurological Deficit, or Neuronal Apoptosis in an Experimental Stroke Model? [J].

Altinay, Serdar ;

Cabalar, Murat ;

Isler, Cihan ;

Yildirim, Funda ;

Celik, Duygu S. ;

Zengi, Oguzhan ;

Tas, Abdurrahim ;

Gulcubuk, Ahmet .

TURKISH NEUROSURGERY, 2017, 27 (04) :537-545

[9]

Amalraj Augustine, 2017, J Tradit Complement Med, V7, P205, DOI 10.1016/j.jtcme.2016.05.005

[10] Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries [J].

Amata, Emanuele ;

Pittala, Valeria ;

Marrazzo, Agostino ;

Parenti, Carmela ;

Prezzavento, Orazio ;

Arena, Emanuela ;

Nabavi, Seyed Mohammad ;

Salerno, Loredana .

CLINICAL SCIENCE, 2017, 131 (14) :1701-1712

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