CRP and SAA1 Haplotypes Are Associated with Both C-Reactive Protein and Serum Amyloid A Levels: Role of Suppression Effects

被引：8

作者：

Ko, Yu-Lin ^{[1
,2
,3
,4
]}

Hsu, Lung-An ^{[5
,6
]}

Wu, Semon ^{[1
,7
]}

Teng, Ming-Sheng ^{[1
]}

Chou, Hsin-Hua ^{[2
,3
]}

机构：

[1] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Res, New Taipei 23142, Taiwan

[2] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Internal Med, Div Cardiol, New Taipei 23142, Taiwan

[3] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Ctr Cardiovasc, New Taipei 23142, Taiwan

[4] Tzu Chi Univ, Sch Med, Hualien 97004, Taiwan

[5] Chang Gung Mem Hosp, Dept Internal Med, Cardiovasc Div 1, Taoyuan 33305, Taiwan

[6] Chang Gung Univ, Coll Med, Taoyuan 33305, Taiwan

[7] Chinese Culture Univ, Dept Life Sci, Taipei 11114, Taiwan

来源：

MEDIATORS OF INFLAMMATION | 2016年 / 2016卷

关键词：

CORONARY-HEART-DISEASE; ACUTE MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE; ARTERY-DISEASE; INFLAMMATORY MARKERS; MISSING HERITABILITY; A PROTEIN; RISK; ATHEROSCLEROSIS; WOMEN;

D O I：

10.1155/2016/5830361

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To test the statistical association of the CRP and SAA1 locus variants with their corresponding circulating levels and metabolic and inflammatory biomarker levels by using mediation analysis, a sample population of 599 Taiwanese subjects was enrolled and five CRP and four SAA1 variants were genotyped. Correlation analysis revealed that C-reactive protein (CRP) and serum amyloid A (SAA) levels were significantly associated with multiple metabolic phenotypes and inflammatory marker levels. Our data further revealed a significant association of CRP and SAA1 variants with both CRP and SAA levels. Mediation analysis revealed that SAA levels suppressed the association between SAA1 genotypes/haplotypes and CRP levels and that CRP levels suppressed the association between CRP haplotypes and SAA levels. In conclusion, genetic variants at the CRP and SAA1 loci independently affect both CRP and SAA levels, and their respective circulating levels act as suppressors. These results provided further evidence of the role of the suppression effect in biological science and may partially explain the missing heritability in genetic association studies.

引用

页数：12

共 42 条

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