Synthesis, crystal structures and in vitro antitumor activities of some organoantimony arylhydroxamates

被引：42

作者：

Wang, GC

Lu, YN

Xiao, J

Yu, L

Song, HB

Li, JS ^{[1
]}

Cui, JR

Wang, RQ

Ran, FX

机构：

[1] Nankai Univ, Sch Chem, State Key Lab Elementoorgn Chem, Tianjin 300071, Peoples R China

[2] Peking Univ, Natl Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2005年 / 690卷 / 01期

关键词：

organoantimony; arylhydroxamic acid; crystal structures; antitumor activity;

D O I：

10.1016/j.jorganchem.2004.09.002

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of novel organoantimony arylhydroxamates with the formulae [Ar3SbL2,](-)[HNEt3](+) (LH = arylhydroxamic acid: Ar = C6H5. 4-CH3C6H4, 3-CH3C6H4, 4-ClC6H4, 4-FC6H4) and (4-CH3C6H4)(4)SbL were synthesized and characterized by elemental analysis, IR. H-1 NMR and mass spectroscopy. The crystal structures of (4-CH3C6H4)(4)SbL and [Ph3SbL2](-)[HNEt3](+) were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against three human cancer cells are reported. (C) 2004 Published by Elsevier B.V..

引用

页码：151 / 156

页数：6

共 31 条

[1]

BARA A, 1991, ANTICANCER RES, V11, P1651

[2]

Bone S. P., 1979, J CHEM RES, V82, P1029

[3] THE CRYSTAL-STRUCTURES OF TETRAPHENYLANTIMONY ACETATE AND ITS ACETIC-ACID ADDUCT [J].