Hypoglycemic and hypolipidemic properties of polysaccharides from Enterobacter cloacae Z0206 in KKAy mice

被引：82
作者：
Huang, Ming [1 ]
Wang, Fengqin [1 ]
Zhou, Xihong [1 ]
Yang, Hangxian [1 ]
Wang, Yizhen [1 ]
机构：
[1] Zhejiang Univ, Coll Anim Sci, Minist Educ, Key Lab Mol Anim Nutr, Hangzhou 310058, Zhejiang, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2015年 / 117卷
关键词：
Type; 2; diabetes; Polysaccharide; Hypoglycemic; KKAy mice; ACTIVATED PROTEIN-KINASE; LYCIUM-BARBARUM POLYSACCHARIDES; INDUCED OXIDATIVE STRESS; INSULIN-RESISTANCE; LIPID-METABOLISM; DIABETES-MELLITUS; MOUSE MODEL; ACID; SIRT1; ATGL;
D O I：
10.1016/j.carbpol.2014.09.008
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The water-soluble polysaccharides (EPS) were isolated from culture broth of Enterobacter cloacae Z0206, and the hypoglycemic and hypolipidemic effects of EPS were investigated. In this study, KKAy mice were gavaged once daily with either distilled water or EPS (200 mg/kg body weight) for 6 weeks. Results showed that EPS possessed significant hypoglycemic effects. Improved oral glucose tolerance, reduced serum insulin levels as well as decreased serum triglycerides (TG), cholesterol (TC) and low density lipoprotein cholesterol (LDL-c) were observed after treatment with EPS. Furthermore, EPS upregulated the expression of glucokinase (GK), HSL (Hormone Sensitive Lipase), adipose triglyceride lipase (ATGL), carnitine palmitoyl transferase (CPT1-ce.), glucose transporter 2 (Glut2), adenosine monophosphate activated protein kinase (AMPK) and silent information regulator 1 (Sirtl), but downregulated the gene expression of glucose-6-phosphata se (G6P) and fatty acid synthase (FAS) in the liver. These results suggest that EPS exhibits hypoglycemic and hypolipidemic effects possibly through regulating AMPK- and SirT1mediated effects on carbohydrate and lipid metabolism. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：91 / 98
页数：8
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