GABAergic astrocytes in Alzheimer's disease

被引：29
作者：
Garaschuk, Olga [1 ]
Verkhratsky, Alexei [1 ]
机构：
[1] Eberhard Karls Univ Tubingen, Dept Neurophysiol, Inst Physiol, Tubingen, Germany
来源：
AGING-US | 2019年 / 11卷 / 06期
关键词：
Alzheimer's disease; plaque vicinity; neuronal hyperactivity; GABA release; astrocyte; MOUSE MODEL; GABA;
D O I：
10.18632/aging.101870
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
引用
收藏
页码：1602 / 1604
页数：3
相关论文
共 7 条
[1]   A bell-shaped dependence between amyloidosis and GABA accumulation in astrocytes in a mouse model of Alzheimer's disease [J].
Brawek, Bianca ;
Chesters, Robert ;
Klement, Daniel ;
Mueller, Julia ;
Lerdkrai, Chommanad ;
Hermes, Marina ;
Garaschuk, Olga .
NEUROBIOLOGY OF AGING, 2018, 61 :187-197
[2]   Network-wide dysregulation of calcium homeostasis in Alzheimer's disease [J].
Brawek, Bianca ;
Garaschuk, Olga .
CELL AND TISSUE RESEARCH, 2014, 357 (02) :427-438
[3]   GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease [J].
Jo, Seonmi ;
Yarishkin, Oleg ;
Hwang, Yu Jin ;
Chun, Ye Eun ;
Park, Mijeong ;
Woo, Dong Ho ;
Bae, Jin Young ;
Kim, Taekeun ;
Lee, Jaekwang ;
Chun, Heejung ;
Park, Hyun Jung ;
Lee, Da Yong ;
Hong, Jinpyo ;
Kim, Hye Yun ;
Oh, Soo-Jin ;
Park, Seung Ju ;
Lee, Hyo ;
Yoon, Bo-Eun ;
Kim, YoungSoo ;
Jeong, Yong ;
Shim, Insop ;
Bae, Yong Chul ;
Cho, Jeiwon ;
Kowall, Neil W. ;
Ryu, Hoon ;
Hwang, Eunmi ;
Kim, Daesoo ;
Lee, C. Justin .
NATURE MEDICINE, 2014, 20 (08) :886-896
[4]   Astrocytes Are GABAergic Cells That Modulate Microglial Activity [J].
Lee, Moonhee ;
Schwab, Claudia ;
Mcgeer, Patrick L. .
GLIA, 2011, 59 (01) :152-165
[5]   Intracellular Ca2+ stores control in vivo neuronal hyperactivity in a mouse model of Alzheimer's disease [J].
Lerdkrai, Chommanad ;
Asavapanumas, Nithi ;
Brawek, Bianca ;
Kovalchuk, Yury ;
Mojtahedi, Nima ;
del Moral, Maria Olmedillas ;
Garaschuk, Olga .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (06) :E1279-E1288
[6]   PHYSIOLOGY OF ASTROGLIA [J].
Verkhratsky, Alexei ;
Nedergaard, Maiken .
PHYSIOLOGICAL REVIEWS, 2018, 98 (01) :239-389
[7]   Tonic inhibition in dentate gyrus impairs long- term potentiation and memory in an Alzhiemer's disease model [J].
Wu, Zheng ;
Guo, Ziyuan ;
Gearing, Marla ;
Chen, Gong .
NATURE COMMUNICATIONS, 2014, 5
1