Computer simulations of lung airway structures using data-driven surface modeling techniques

被引:24
作者
Spencer, RM
Schroeter, JD
Martonen, TB
机构
[1] US EPA, Expt Toxicol Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA
[2] US EPA, Sci Visualizat Lab, Lockheed Martin, Res Triangle Pk, NC 27711 USA
[3] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Dept Med, Div Pulm Dis, Chapel Hill, NC 27599 USA
关键词
computer simulations; lung morphology; airway structure; surface modeling; NURBS surfaces; computational fluid dynamics; aerosol therapy;
D O I
10.1016/S0010-4825(01)00020-8
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Knowledge of human lung morphology is a subject critical to many areas of medicine. The visualization of lung structures naturally lends itself to computer graphics modeling due to the large number of airways involved and the complexities of the branching systems. In this study, a method of generating three-dimensional computer simulations of human lung airway networks using data-driven, surface modeling techniques is presented. By simulating the tubular airway structures and realistic bifurcation shapes, anatomically accurate representations of human lungs are obtained. These computer models are designed for use in computational fluid dynamic applications and particle trajectory analyses, and to be complimentary to medical imaging (gamma scintigraphy) protocols. (C) 2001 Published by Elsevier Science Ltd.
引用
收藏
页码:499 / 511
页数:13
相关论文
共 40 条
  • [1] CHARACTERIZING LUNG AEROSOL PENETRATION
    AGNEW, JE
    [J]. JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 1991, 4 (03): : 237 - 249
  • [2] [Anonymous], 1994, HUM RESP TRACT MOD R
  • [3] [Anonymous], RES PRIOR AIRB PART
  • [4] INERTIAL AND GRAVITATIONAL DEPOSITION OF PARTICLES IN A SQUARE CROSS-SECTION BIFURCATING AIRWAY
    ASGHARIAN, B
    ANJILVEL, S
    [J]. AEROSOL SCIENCE AND TECHNOLOGY, 1994, 20 (02) : 177 - 193
  • [5] Dolovich M A, 2000, Respir Care, V45, P597
  • [6] ECKEL G, 1998, OPENGL OPTIMIZER PRO
  • [7] ECKEL G, 1998, COSMO3D PROGRAMMERS
  • [8] A technique for simulating radionuclide images from the aerosol deposition pattern in the airway tree
    Fleming, JS
    Hashish, AH
    Conway, JH
    HartleyDavies, R
    Nassim, MA
    Guy, MJ
    Coupe, J
    Holgate, ST
    Moore, E
    Bailey, AG
    Martonen, TB
    [J]. JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 1997, 10 (03): : 199 - 212
  • [9] DESCRIPTION OF PULMONARY DEPOSITION OF RADIOLABELED AEROSOL BY AIRWAY GENERATION USING A CONCEPTUAL 3-DIMENSIONAL MODEL OF LUNG MORPHOLOGY
    FLEMING, JS
    NASSIM, M
    HASHISH, AH
    BAILEY, AG
    CONWAY, J
    HOLGATE, S
    HALSON, P
    MOORE, E
    MARTONEN, TB
    [J]. JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 1995, 8 (04): : 341 - 356
  • [10] Foley J., 1997, COMPUTER GRAPHICS PR