Structure Formation and Catalytic Activity of DNA Dissolved in Organic Solvents

被引：45

作者：

Abe, Hiroshi ^{[1
,2
]}

Abe, Naoko ^{[1
]}

Shibata, Aya ^{[1
]}

Ito, Keiji ^{[1
,3
]}

Tanaka, Yoshiyuki ^{[4
]}

Ito, Mika ^{[5
]}

Saneyoshi, Hisao ^{[1
]}

Shuto, Satoshi ^{[5
]}

Ito, Yoshihiro ^{[1
]}

机构：

[1] RIKEN Adv Sci Inst, Nano Med Engn Lab, Wako, Saitama 3510198, Japan

[2] PRESTO Japan Sci & Technol Agcy Japan, Tokyo, Japan

[3] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1138654, Japan

[4] Tohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi 980, Japan

[5] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 060, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 26期

关键词：

DNA; G-quadruplexes; nucleic acids; porphyrinoids; structure-activity relationships; G-QUADRUPLEX STRUCTURES; COORDINATION COMPLEX; TELOMERIC DNA; G-TETRAPLEX; CAST FILM; STABILITY; BINDING; SEQUENCE; ENZYMES; HEMIN;

D O I：

10.1002/anie.201201111

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Equal-opportunity dissolver: By attaching polyethylene glycol at its 5' end, DNA (PEG-DNA) can be solubilized in various organic solvents and was shown to form G-quadruplexes by CD spectroscopy. A complex containing iron(III) protoporphyrin IX (hemin) and G-quadruplex-forming PEG-DNA catalyzed an oxidative reaction in methanol (see scheme). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6475 / 6479

页数：5

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