The hippocratic finger points the blame at PGE2

被引:22
作者
Coggins, Kenneth G. [1 ]
Coffman, Thomas M. [2 ]
Koller, Beverly H. [3 ,4 ]
机构
[1] Carolinas Med Ctr, Dept Med, Charlotte, NC 28203 USA
[2] Duke Univ, Dept Med, Div Nephrol, Durham, NC 27710 USA
[3] Univ N Carolina, Dept Genet, Div Pulm & Crit Care, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Dept Med, Div Pulm & Crit Care, Chapel Hill, NC 27599 USA
关键词
D O I
10.1038/ng0608-691
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Digital clubbing has been recognized since the time of the ancient Greeks as a sign of systemic disease. Now, a new study identifies a role for prostaglandin E2 in the pathogenesis of digital clubbing observed in familial hypertrophic osteoarthropathy.
引用
收藏
页码:691 / 692
页数:2
相关论文
共 14 条
[1]   Vascular endothelial growth factor (VEGF)-A and platelet-derived growth factor (PDGF) play a central role in the pathogenesis of digital clubbing [J].
Atkinson, S ;
Fox, SB .
JOURNAL OF PATHOLOGY, 2004, 203 (02) :721-728
[2]   TOXIC EFFECTS OF INTRAVENOUS AND ORAL PROSTAGLANDIN-E THERAPY IN PATIENTS WITH LIVER-DISEASE [J].
CATTRAL, MS ;
ALTRAIF, I ;
GREIG, PD ;
BLENDIS, L ;
LEVY, GA .
AMERICAN JOURNAL OF MEDICINE, 1994, 97 (04) :369-373
[3]   Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus [J].
Coggins, KG ;
Latour, A ;
Nguyen, MS ;
Audoly, L ;
Coffman, TM ;
Koller, BH .
NATURE MEDICINE, 2002, 8 (02) :91-92
[4]  
DICKINSON CJ, 1987, LANCET, V2, P1434
[5]   THE ARTHROPATHY OF CYSTIC-FIBROSIS [J].
DIXEY, J ;
REDINGTON, AN ;
BUTLER, RC ;
SMITH, MJ ;
BATCHELOR, JR ;
WOODROW, DF ;
HODSON, ME ;
BATTEN, JC ;
BREWERTON, DA .
ANNALS OF THE RHEUMATIC DISEASES, 1988, 47 (03) :218-223
[6]   Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation [J].
Fabre, JE ;
Nguyen, M ;
Athirakul, K ;
Coggins, K ;
McNeish, JD ;
Austin, S ;
Parise, LK ;
FitzGerald, GA ;
Coffman, TM ;
Koller, BH .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (05) :603-610
[7]   Thyroid acropachy: Report of 40 patients treated at a single institution in a 26-year period [J].
Fatourechi, V ;
Ahmed, DDF ;
Schwartz, KM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (12) :5435-5441
[8]   ASSOCIATION BETWEEN PLATELET MICROTHROMBI AND FINGER CLUBBING [J].
FOX, SB ;
DAY, CA ;
GATTER, KC .
LANCET, 1991, 338 (8762) :313-314
[9]   FINGER CLUBBING IN INFLAMMATORY BOWEL-DISEASE - ITS PREVALENCE AND PATHOGENESIS [J].
KITIS, G ;
THOMPSON, H ;
ALLAN, RN .
BMJ-BRITISH MEDICAL JOURNAL, 1979, 2 (6194) :825-828
[10]   PRIMARY HYPERTROPHIC OSTEOARTHROPATHY - ANOTHER HERITABLE DISORDER ASSOCIATED WITH PATENT DUCTUS-ARTERIOSUS [J].
MARTINEZLAVIN, M ;
PINEDA, C ;
NAVARRO, C ;
BUENDIA, A ;
ZABAL, C .
PEDIATRIC CARDIOLOGY, 1993, 14 (03) :181-182