Ionic-Surfactant-Coated Burkholderia cepacia Lipase as a Highly Active and Enantioselective Catalyst for the Dynamic Kinetic Resolution of Secondary Alcohols

被引：58

作者：

Kim, Hyunjin ^{[1
]}

Choi, Yoon Kyung ^{[1
]}

Lee, Jusuk ^{[1
]}

Lee, Eungyeong ^{[1
]}

Park, Jaiwook ^{[1
]}

Kim, Mahn-Joo ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol POSTECH, Dept Chem, Pohang 790784, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 46期

基金：

新加坡国家研究基金会;

关键词：

alcohols; catalysts; dynamic kinetic resolution; lipases; ruthenium; ASYMMETRIC REDUCTIVE ACYLATION; PSEUDOMONAS-CEPACIA; RACEMIZATION CATALYSTS; AMBIENT-TEMPERATURE; AMINES; ENANTIOMER; DKR;

D O I：

10.1002/anie.201104141

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

With a coat for activity: A highly active enzyme was prepared by coating Burkholderia cepacia lipase with an ionic surfactant for use in dynamic kinetic resolution (DKR). Important features of this enzyme include: the fastest DKR of 1-phenylethanol, the highly enantioselective DKR of a wide range of secondary alcohols (RCH(OH)Ar), and the switching of lipase enantioselectivity in DKR depending on the shape of the aliphatic chain (R). © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：10944 / 10948

页数：5

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