Interleukines in chronic viral hepatitis

被引：0

作者：

Loginov, AS ^{[1
]}

Tsaregorodtseva, TA ^{[1
]}

Zotina, MA ^{[1
]}

Serova, TI ^{[1
]}

Yakimchuk, GN ^{[1
]}

Fedotova, TF ^{[1
]}

机构：

[1] Moscow Cent Gastroenterol Res Inst, Moscow, Russia

来源：

TERAPEVTICHESKII ARKHIV | 2001年 / 73卷 / 02期

关键词：

chronic viral hepatitis; interleukines; cytokines;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim. To estimate interleukines levels in chronic hepatitis (CH) in respect to CH etiological factor, activity and stage. Material and methods. Enzyme immunoassay (kits from proteinovy Kontur, St-Petersburg) determined levels of IL-1beta, IL-4, IL-6 and TNF-alpha in the peripheral blood of 250 patients with chronic hepatitis C (CHC), B (CHB), D (CHD) and G (CHG). Results. IL concentrations in chronic viral hepatitis depend on etiological factor (CHC, CHB, CHD, CHG), activity (high, moderate, low), stage (chronic hepatitis, cirrhosis). IL occur in high quantities it? CHC, in moderate concentrations in CHB and in minimal ones in CHG. Maximal IL levels were observed in high hepatitis activity at the stage of hepatic cirrhosis. TNF-alpha and IL-4 concentrations rose more frequently and higher than IL-6 and IL-1beta (43 and 34%, tip to 315 pg/ml and 256 pg/ml, respectively).

引用

页码：17 / 20

页数：4

共 12 条

[1]

ANDUS T, 1991, HEPATOLOGY, V13, P364, DOI 10.1016/0270-9139(91)92454-G

[2]

BUKOVSKAYA SN, 1995, IMMUNOLOGIYA, V6, P45

[3]

Huang Y S, 1999, Zhonghua Yi Xue Za Zhi (Taipei), V62, P327

[4] The nature of Helicobacter pylori [J].

Lee, A .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1996, 31 :5-8

[5]

LOHR HF, 1994, LIVER, V14, P161

[6]

LYASHENKO AA, 1999, DOKAZATELNAYA MED MO, P150

[7]

MCCLAIN C, 1991, HEPATOLOGY, V13, P27

[8]

NAKANUMA Y, 1998, LAB INVEST, V78, P89

[9]

SHERLOK S, 1999, ZABOLEVANIYA PECHENI, P92

[10] Cytokine mRNA expression in the liver of patients with primary biliary cirrhosis (PBC) and chronic hepatitis B (CHB) [J].

Shindo, M ;

Mullin, GE ;

BraunElwert, L ;

Bergasa, NV ;

Jones, EA ;

James, SP .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1996, 105 (02) :254-259

← 1 2 →