Metabolism of GABA in retina of diabetic rat

被引：0

作者：

Honda, M

Ino-ue, M

Okada, Y

Yamamoto, M

机构：

[1] Kobe Univ, Sch Med, Dept Ophthalmol, Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Kobe Univ, Sch Med, Dept Physiol, Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

NEUROSCIENCE RESEARCH COMMUNICATIONS | 1999年 / 24卷 / 01期

关键词：

GABA; retina; metabolic change; diabetes mellitus;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of hyperglycemia on the localization and metabolism of gamma-aminobutyric acid (GABA) was examined to elucidate the pathogenesis of deteriorations of electroretinogram oscillatory potentials in streptozotocin-induced diabetic rats. GABA is localized primarily in amacrine cells in the diabetic retina. GABA content and activities of glutamate decarboxylase (GAD) and GABA transaminase (GABA-T) in the retina and superior colliculus (SC) were determined. GABA content and activities of GAD and GABA-T remained unchanged in retinas and SCs of diabetic rats. Alterations in the GABAnergic system of the retina could not be observed. GABA metabolism may have no relation with visual dysfunction in diabetes mellitus.

引用

页码：27 / 32

页数：6

共 10 条

[1] Elevated gamma-aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy [J].