High-grade Astrocytoma (Glioblastoma Multiforme) in an Atlantic Spotted Dolphin (Stenella frontalis)

被引：7

作者：

Diaz-Delgado, J. ^{[1
]}

Sacchini, S. ^{[1
]}

Suarez-Bonnet, A. ^{[1
]}

Sierra, E. ^{[1
]}

Arbelo, M. ^{[1
]}

Espinosa, A. ^{[1
]}

Rodriguez-Grau Bassas, E. ^{[2
]}

Mompeo, B. ^{[1
]}

Perez, L. ^{[1
]}

Fernandez, A. ^{[1
]}

机构：

[1] Univ Las Palmas Gran Canaria, Inst Anim Hlth, Dept Morphol, Div Histol & Anim Pathol, Las Palmas Gran Canaria, Canary Islands, Spain

[2] Univ Las Palmas Gran Canaria, Div Oncol & Comparat Surg, Las Palmas Gran Canaria, Canary Islands, Spain

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2015年 / 152卷 / 2-3期

关键词：

astrocytoma; Atlantic spotted dolphin; brain; immunohistochemistry;

D O I：

10.1016/j.jcpa.2014.12.016

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

This report describes the gross, microscopical and immunohistochemical features of a high-grade astrocytoma (glioblastoma multiforme) in an adult male Atlantic spotted dolphin (Stenella frontalis). On necropsy examination, a 5 x 2.5 x 2 cm, poorly demarcated, red, friable and locally expansile mass effaced the thalamus and the left periventricular region and extended to the left lateral ventricle of the brain. Microscopically, the mass consisted of haphazardly arranged bundles and rows of interweaving polygonal to spindle-shaped cells. These often palisaded along serpentine foci of necrosis and were surrounded by prominent vessels. Immunohistochemically, the neoplastic cells expressed glial fibrillary acidic protein, but not vimentin, S100 protein, neuron-specific enolase or neurofilament protein. A diagnosis of high-grade astrocytoma was made and this represents the first description of a glioma in a cetacean species. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：278 / 282

页数：5

共 19 条

[1]

[Anonymous], 2007, COMP ONCOLOGY CHAP 3

[2] Primary Central Nervous System T-Cell Lymphoma in a Common Dolphin (Delphinus delphis) [J].

Arbelo, M. ;

Espinosa de los Monteros, A. ;

Herraez, P. ;

Suarez-Bonnet, A. ;

Andrada, M. ;

Rivero, M. ;

Grau-Bassas, E. R. ;

Fernandez, A. .

JOURNAL OF COMPARATIVE PATHOLOGY, 2014, 150 (2-3) :336-340

[3] Pathology and causes of death of stranded cetaceans in the Canary Islands (1999-2005) [J].

Arbelo, Manuel ;

Espinosa de los Monteros, Antonio ;

Herraez, Pedro ;

Andrada, Marisa ;

Sierra, Eva ;

Rodriguez, Francisco ;

Jepson, Paul D. ;

Fernandez, Antonio .

DISEASES OF AQUATIC ORGANISMS, 2013, 103 (02) :87-99

[4] Primitive Neuroectodermal Tumour in a Striped Dolphin (Stenella coeruleoalba) with Features of Ependymoma and Neural Tube Differentiation (Medulloepithelioma) [J].

Baily, J. L. ;

Morrison, L. R. ;

Patterson, I. A. ;

Underwood, C. ;

Dagleish, M. P. .

JOURNAL OF COMPARATIVE PATHOLOGY, 2013, 149 (04) :514-519

[5]

Delyamure SL, 1955, ACAD SCI USSR TRANSL

[6]

Kuiken Thijs, 1991, P1

[7]

Kumar V, 2014, CENTRAL NERVOUS SYST, P1251

[8]

Lorenz M.D., 2011, Handbook of Veterinary Neurology, V5th, P37

[9]

Louis DN, 2007, WHO CLASSIFICATION T, P17

[10]

Maxie M.G., 2007, Jubb, Kennedy, and Palmer's Pathology of Domestic Animals

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