Optimal adaptive control of a bioprocess with yield-productivity conflict

被引：15

作者：

Jadot, F

Bastin, G

Van Impe, JF

机构：

[1] Catholic Univ Louvain, Ctr Syst Engn & Appl Mech, B-1348 Louvain, Belgium

[2] Katholieke Univ Leuven, Lab Ind Microbiol & Biochem, B-3001 Louvain, Belgium

来源：

JOURNAL OF BIOTECHNOLOGY | 1998年 / 65卷 / 01期

关键词：

biotechnology; multicriteria optimization; feedback control; adaptive algorithms;

D O I：

10.1016/S0168-1656(98)00122-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This paper is concerned with the optimization of biological production processes. The process is characterized by a conflict between yield and productivity as revealed by the analysis of the model. The optimization problem is to find an operating mode that achieves the best trade off between yield and productivity. It is shown how this problem can be formulated as a parametric optimization involving parameters that have a clear engineering meaning. This parametric optimization leads to the definition of a control problem which requires a feedback implementation under the form of an adaptive regulator combined with a software sensor. A simple mechanistic model is considered as a benchmark example for this optimization study. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：61 / 68

页数：8

共 4 条

[1]

Bastin G., 1990, On-line Estimation and Adaptive Control of Bioreactors

[2] COMPUTATIONAL ALGORITHMS FOR OPTIMAL FEED RATES FOR A CLASS OF FED-BATCH FERMENTATION - NUMERICAL RESULTS FOR PENICILLIN AND CELL MASS-PRODUCTION [J].