Synthesis of Furo[2,3-e][1,4]diazepin-3-one Derivatives through Tandem Cyclization/[4+3] Annulation Reactions

被引：15

作者：

Zhang, Bei ^{[1
]}

Yu, Jinhang ^{[1
]}

Wu, Xin ^{[1
]}

Chai, Zeyu ^{[1
]}

Zhao, Guoying ^{[1
]}

Li, Zihan ^{[1
]}

Kang, Honglan ^{[1
]}

Lv, Xin ^{[1
]}

Zhou, Liejin ^{[1
]}

机构：

[1] Zhejiang Normal Univ, Coll Chem & Life Sci, Key Lab, Minist Educ Adv Catalysis Mat, Jinhua 321004, Zhejiang, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; GOLD; CYCLOADDITION; 2-(1-ALKYNYL)-2-ALKEN-1-ONES; HETEROCYCLIZATION; DISCOVERY; RECEPTOR; 1,4-DIAZEPINES; INHIBITORS; FACILE;

D O I：

10.1021/acs.joc.1c02561

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of furo[2,3-e][1,4]diazepin-3-one derivatives were facilely synthesized through one-pot tandem cyclization/ [4 + 3] annulation reactions between enynamides and alpha-bromohydroxa- mates. The reactions proceeded efficiently at room temperature, and various functional groups were well tolerated. The obtained furo [2,3- e][1,4]diazepin-3(2H)-ones containing a 7-membered dinitrogen- fused ring might be of biological and medicinal value. The products could be further derived using convenient procedures.

引用

页码：3668 / 3676

页数：9

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